Index Catalog // ScholarsArchive@OSU

Transcriptional regulation of the human cathelicidin antimicrobial peptide gene

Creator:: Guo, Chunxiao
Abstract:: Human cathelicidin antimicrobial peptide (CAMP/LL-37) is a cationic antimicrobial peptide that is widely expressed by myeloid and epithelial cells at the human-environment interface. It possesses broad spectrum antimicrobial capacity against bacteria, fungi and viruses. In addition to its direct antimicrobial activity, CAMP/LL-37 also attracts and recruits monocytes, neutrophils and other...
Resource Type:: Dissertation
Full Text:: Antimicrobial Peptide Gene

The effect of dietary compounds on human cathelicidin antimicrobial peptide gene expression mediated through farnesoid X receptor and its potential role in gastrointestinal health

Creator:: Campbell, Yan
Abstract:: The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum microbicidal agent and modulator of both the innate and adaptive immune system. It is induced by 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) through activation of the vitamin D receptor (VDR) and primary bile salts through activation of the xenobiotic nuclear receptor farnesoid X...
Resource Type:: Dissertation
Full Text:: ………………………………………………………………. 91 4.6. Vitamin D deficiency decreases the expression of the human CAMP gene in the salivary

Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway

Creator:: Guo, Chunxiao, Rosoha, Elena, Lowry, Malcolm B., Borregaard, Niels, and Gombart, Adrian F.
Abstract:: The vitamin D receptor (VDR) mediates the pleiotropic biologic effects of 1alpha,25 dihydroxy-vitamin D3. Recent in vitro studies suggested that curcumin and poly-unsaturated fatty acids (PUFAs) also bind to VDR with low affinity. As potential ligands for the VDR, we hypothesized that curcumin and PUFAs would induce expression of known...
Resource Type:: Article
Full Text:: peptide gene expression through a vitamin D receptor-independent pathway Chunxiao Guo a,b

The function of the homeobox transcription factor Pitx2 during mammalian skeletal muscle development

Creator:: Shih, Hung Ping
Abstract:: Homeodomain transcription factors control developmental processes. They pattern body formation, specify cell lineages and switch the onset of gene regulatory cascades. Pitx2, a bicoid-related homeodomain transcription factor, is asymmetrically expressed in the left lateral plate mesoderm and mesoderm-derived tissues. Pitx2 null mice are characterized by failure of body wall closure,...
Resource Type:: Dissertation
Full Text:: the onset of gene regulatory cascades. Pitx2, a bicoid-related homeodomain transcription factor, is

Adenovirus replication in trans : a new replication pathway

Creator:: Ahern, Kevin
Abstract:: Replication of plasmid molecules containing either a left-end or a right-end adenovirus origin was investigated. When the plasmids were linearized to expose their respective adenovirus termini, mixed, and transfected with helper adenovirus DNA into the human 293 cell line, a new molecule was detected. The new molecule was the size...
Resource Type:: Dissertation
Full Text:: Abstract approved: Redacted for privacy fir. George D. Pearson Replication of plasmid molecules

The asymmetric binding of Actinomycin D to DNA hexamers

Creator:: Ivancic, Monika
Abstract:: The solution structure determination of DNA molecules has been an important part of structural biology. NMR solution structures are a complement to structures solved via X-ray crystallography; the two methods are the only ways of obtaining three dimensional coordinates of macromolecules. Because of the nature of the molecule, the solution...
Resource Type:: Dissertation
Full Text:: of the anti-cancer drug Actinomycin D (ActD) and DNA used self- Redacted for Privacy

Bacteriophage T4 ribonucleotide reductase : genes and proteins

Creator:: Hanson, Eric Scott
Resource Type:: Dissertation
Full Text:: reductases designed to function under aerobiosis and anaerobiosis. The T4 nrdA gene and intron-containing

Organization of T4 bacteriophage genes and gene products involved in DNA precursor biosynthesis

Creator:: Wang, Yeong
Abstract:: Bacteriophage T4 gene 42 encodes dCMP hydroxymethylase, an enzyme unique to the deoxyribonucleotide metabolism of T-even bacteriophages. To study biochemical and biophysical properties of the enzyme, as well as the interaction of dCMP hydroxymethylase with other DNA precursor biosynthetic enzymes in vitro, availability of large amounts of the enzyme is...
Resource Type:: Dissertation
Full Text:: Organization of T4 bacteriophage genes and gene products

Exogenous gene expression from heterologous promoters in fish cell cultures

Creator:: Sharps, Angela
Abstract:: Cell culture systems have provided many insights into eukaryotic gene expression and other biochemical mechanisms. Since the cell represents the smallest living unit of any organism it provides a desirable in vitro system, allowing biochemical studies without the complex physiology of an entire animal. However, processes involving intracellular mechanisms, such...
Resource Type:: Masters Thesis
Full Text:: developmental biology, gene and growth regulation, disease and within the immune system (Hanahan D., 1989

Vaccinia virus ribonucleotide reductase : regulation of the gene products and characterization of the recombinant small subunit protein

Creator:: Howell, Meredith L.
Abstract:: Ribonucleotide reductase is a remarkable enzyme that catalyzes the rate-limiting step in the synthesis of the 2'-deoxynucleoside triphosphates. The intent of this project was to characterize the ribonucleotide reductase encoded by the orthopoxvirus, vaccinia. The first objective was to study the structural and functional features of the viral small subunit...
Resource Type:: Dissertation
Full Text:: the gene products and characterization of the recombinant small subunit protein AN ABSTRACT OF THE

ScholarsArchive@OSU

Transcriptional regulation of the human cathelicidin antimicrobial peptide gene

The effect of dietary compounds on human cathelicidin antimicrobial peptide gene expression mediated through farnesoid X receptor and its potential role in gastrointestinal health

Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway

The function of the homeobox transcription factor Pitx2 during mammalian skeletal muscle development

Adenovirus replication in trans : a new replication pathway

The asymmetric binding of Actinomycin D to DNA hexamers

Bacteriophage T4 ribonucleotide reductase : genes and proteins

Organization of T4 bacteriophage genes and gene products involved in DNA precursor biosynthesis

Exogenous gene expression from heterologous promoters in fish cell cultures

Vaccinia virus ribonucleotide reductase : regulation of the gene products and characterization of the recombinant small subunit protein

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