Index Catalog // ScholarsArchive@OSU

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Creator:: Padgitt-Cobb, Lillian K.
Abstract:: Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
Resource Type:: Dissertation

Structural studies of the antioxidant defense enzymes; copper, zinc superoxide dismutase and alkyl hydroperoxide reductase flavoprotein

Creator:: Roberts, Blaine R.
Abstract:: Oxygen derived radicals are involved in many aspects of life from aging and cell signaling to disease states as diverse as heart disease, diabetes, neurodegeneration and inflammation. Therefore, understanding the function of antioxidant defense proteins and the effects of oxygen derived radicals on protein function is essential to elucidate the...
Resource Type:: Dissertation

Building a bridge from chromosomes to microtubules in Neurospora crassa

Creator:: Friedman, Steven
Abstract:: DNA is often described as the “blueprint for life”. In eukaryotes this information is contained within linear chromosomes of varying size and number. During cell division, the chromosomes must be faithfully segregated into each daughter cell to avoid disease and sustain life. This process is carried out by the kinetochore...
Resource Type:: Dissertation
Full Text:: (L. Connolly, S. Shahi, M. Rep, L. Fokkens, S.-H. Yun and M. Freitag, in preparation) than what is

Transcriptional regulation of the human cathelicidin antimicrobial peptide gene

Creator:: Guo, Chunxiao
Abstract:: Human cathelicidin antimicrobial peptide (CAMP/LL-37) is a cationic antimicrobial peptide that is widely expressed by myeloid and epithelial cells at the human-environment interface. It possesses broad spectrum antimicrobial capacity against bacteria, fungi and viruses. In addition to its direct antimicrobial activity, CAMP/LL-37 also attracts and recruits monocytes, neutrophils and other...
Resource Type:: Dissertation

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

Creator:: Otto, Shauna C.
Abstract:: Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...
Resource Type:: Dissertation

The Role of Cellular Senescence in the Development of Alzheimer's Disease

Creator:: Riordan, Ruben
Abstract:: Alzheimer’s Disease (AD) is a neurodegenerative pathology currently affecting nearly 44 million individuals worldwide, yet there are not currently any effective treatments or preventions for AD despite the rapid development in our understanding of the disease over the last four decades. The medical and sanitary innovations of the last century...
Resource Type:: Dissertation
Full Text:: ; Yun et al, 2015). Cellular senescence is most commonly known for its role in tumor suppression and

Protein Disorder in the Evolution of Dynein Regulation

Creator:: Jie, Jing
Abstract:: Intrinsically disordered proteins (IDP) are a class of proteins that lack a three-dimensional structure and their prevalence and diverse functions in the cell have only been discovered relatively recently. The intermediate chain (IC) subunit of the microtubule motor protein complex dynein contains an N-terminal disordered region, N-IC, which is central...
Resource Type:: Dissertation

Characterization of the mechanism and function of C₂H₂ zinc finger protein CTIP2 in the developmental processes

Creator:: Golonzhka, Olga
Abstract:: CTIP2 is a C2H2 zinc finger transcription factor that plays important yet poorly understood roles in mouse development. CTIP2 is known to be highly expressed in the central nervous system, skin and T lymphocytes during embryogenesis. CTIP2-null mice die perinatally of unknown causes and exhibit defects in multiple organ systems...
Resource Type:: Dissertation

Towards a Better Understanding of How the Dietary Supplement Xanthohumol Can Improve Health

Creator:: Logan, Isabelle E.
Abstract:: Xanthohumol, a prenylated flavonoid found in hops and beer, possesses a long-standing reputation to improve health. Xanthohumol’s cytotoxicity to a wide variety of cancer cell lines is well-established. Herein we provide further insight into the cytotoxicity of not only xanthohumol, but also its non-estrogenic derivatives, to a number of colonic...
Resource Type:: Dissertation

Host kinases involved in DNA precursor biosynthesis during bacteriophage T4 infection

Creator:: Bernard, Mark Aguirre
Abstract:: Although the Escherichia coli host has almost all of the enzymes necessary to synthesize nucleotides needed for bacteriophage T4 DNA replication, phage genes expressed early in infection encode enzymes for de novo DNA precursor biosynthesis and salvage from degraded host DNA. Eight early enzymes and two host enzymes comprise the...
Resource Type:: Dissertation
Full Text:: protein). Hui-Yun Zhang and Jake Zelenka each provided some of the NDP kinase used in this work. Dr

ScholarsArchive@OSU

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Structural studies of the antioxidant defense enzymes; copper, zinc superoxide dismutase and alkyl hydroperoxide reductase flavoprotein

Building a bridge from chromosomes to microtubules in Neurospora crassa

Transcriptional regulation of the human cathelicidin antimicrobial peptide gene

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

The Role of Cellular Senescence in the Development of Alzheimer's Disease

Protein Disorder in the Evolution of Dynein Regulation

Characterization of the mechanism and function of C₂H₂ zinc finger protein CTIP2 in the developmental processes

Towards a Better Understanding of How the Dietary Supplement Xanthohumol Can Improve Health

Host kinases involved in DNA precursor biosynthesis during bacteriophage T4 infection

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