Index Catalog // ScholarsArchive@OSU

Comprehensive Analysis of The Brain Metabolome Using Mass Spectrometry in Conjunction with Data Analysis Techniques

Creator:: Khorani, Mona
Abstract:: Metabolomics has recently gained momentum in biomolecule research and complements the genomics and proteomics research space. Metabolomics strives to detect, identify, and quantify all metabolites present in biological samples. In particular, biomolecular analysis using ultra-performance liquid chromatography combined with mass spectrometry (UPLC-MS) has become increasingly important for metabolomic analyses. Similarly,...
Resource Type:: Dissertation

A Pyrone Diels–Alder Approach to Substituted Indoles and Carbazoles and the Synthesis of New Ropinirole Analogues

Creator:: Points, Gary L., III
Abstract:: Aromatic heterocycles are core structural motifs in natural products, pharmaceuticals and biological polymers. Indoles, in particular, represent a significant subclass of aromatic heterocycles, both in terms of sheer numbers, but also in biological and pharmaceutical relevance. As such, new methodologies for the synthesis of indoles represent an important and continually...
Resource Type:: Dissertation
Full Text:: : Lane Tidwell, Stephen O’Connell, Jessica Vellucci, Alan Bergman, Blair Paulik, Carey Donald and

Capturing Molecular Movies of Organic and Organometallic Systems in Solution by Ultrafast Spectroscopy

Creator:: Boulanger, Sean A.
Abstract:: Ultrafast spectroscopy can exploit the structure-function relationship of chemical- and biological-based systems. More specifically, femtosecond stimulated Raman spectroscopy (FSRS) provides ground- and excited-state vibrational information with simultaneously high spectral (spatial) and temporal resolutions. The electronic counterpart, femtosecond transient absorption (fs-TA), complements FSRS data analysis as part of a comprehensive approach...
Resource Type:: Dissertation
Full Text:: bond dissociation of a bimetallic complex, triphenylbismuth–tungsten pentacarbonyl (Ph3Bi–W(CO)5

New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

Creator:: Overacker, Ross D.
Abstract:: Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...
Resource Type:: Dissertation
Full Text:: increasing concentrations of 4.2 by weight (w/w) (4.2 elutes at 10 min). (B) Binding sensorgrams of each O1

Exploratory Studies Within the Exotic Lyonsite Structure

Creator:: Tang, Joseph N.
Abstract:: Structure-property relationships have always underpinned the field of solid state chemistry; dependable structural descriptions are integral to understanding and controlling the physical properties of inorganic compounds old and new. While a handful of crystal structures are celebrated for their versatility, flexibility, and functionality, the existence of more exotic structures is...
Resource Type:: Dissertation
Full Text:: with his life lessons, and Drs. Donald Wharry, Mary Kopecki, and J.D. Lewis, for sparking my interest

New chemistry for electrochemical energy storage applications

Creator:: Wang, Xingfeng
Abstract:: Electrochemical capacitors and batteries are two major electrochemical energy storage technologies, which have been investigated extensively to meet the rapidly-growing demand for higher energy, higher power, lower cost and enhanced safety in the past few decades. With the charge storage mechanism of electrostatic charge adsorption desorption via electrical double layers,...
Resource Type:: Dissertation
Full Text:: a par with state-of-the-art non-aqueous capacitors, while delivering a maximum power of 6222 W/kg

Local scale spatial and temporal variation in wet deposition of persistent organic pollutants by snow

Creator:: Walsh, Christopher D.
Abstract:: The objective of this research was to assess the variability of POP deposition by snow on a 10 km spatial scale by measuring the POP concentrations in fresh-fallen snow from remote alpine sites. Samples of pre-metamorphic snow were concurrently collected from three remote alpine sites, of matched altitude and exposure,...
Resource Type:: Dissertation
Full Text:: .; Schindler, D. W.; Muir, D. C. G.; Kimpe, L. E.; Donald, D. B.; Rosenberg, B., Accumulation of persistent

Hydrogen/deuterium exchange mass spectrometry as a technology platform for studying conformational dynamics in large protein complexes

Creator:: Nirudodhi, Sasidhar N.
Abstract:: Proteins are essential to all biological systems. Proteins participate in numerous cellular processes by interacting with other proteins, other metabolites and membranes in a dynamic environment. Studying the structural and conformational properties of proteins in the solution phase is necessary to understand their protein folding and interaction dynamics. This research...
Resource Type:: Dissertation

The kinetic and radiolytic aspects of control of the redox speciation of neptunium in solutions of nitric acid

Creator:: Precek, Martin
Abstract:: Neptunium, with its rich redox chemistry, has a special position in the chemistry of actinides. With a decades-long history of development of aqueous separation methods for used nuclear fuel (UNF), management of neptunium remains an unresolved issue because of its not clearly defined redox speciation. Neptunium is present in two,...
Resource Type:: Dissertation

Analytical method development for the identification, detection, and quantification of emerging environmental contaminants in complex matrices

Creator:: Place, Benjamin J.
Abstract:: The development of analytical methods for emerging contaminants creates many unique challenges for analytical chemists. By their nature, emerging contaminants have inherent data gaps related to their environmental occurrence, fate, and impact. This dissertation is a compilation of three studies related to method development for the structural identification of emerging...
Resource Type:: Dissertation
Full Text:: . Technol. 1999, 33, (16), 2800-2806. 12 11. Moody, C. A.; Martin, J. W.; Kwan, W. C.; Muir, D. C

ScholarsArchive@OSU

Comprehensive Analysis of The Brain Metabolome Using Mass Spectrometry in Conjunction with Data Analysis Techniques

A Pyrone Diels–Alder Approach to Substituted Indoles and Carbazoles and the Synthesis of New Ropinirole Analogues

Capturing Molecular Movies of Organic and Organometallic Systems in Solution by Ultrafast Spectroscopy

New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

Exploratory Studies Within the Exotic Lyonsite Structure

New chemistry for electrochemical energy storage applications

Local scale spatial and temporal variation in wet deposition of persistent organic pollutants by snow

Hydrogen/deuterium exchange mass spectrometry as a technology platform for studying conformational dynamics in large protein complexes

The kinetic and radiolytic aspects of control of the redox speciation of neptunium in solutions of nitric acid

Analytical method development for the identification, detection, and quantification of emerging environmental contaminants in complex matrices

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