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Filtering by: Creator Nakayama, Karina H. Remove constraint Creator: Nakayama, Karina H. Academic Affiliation Chemistry Remove constraint Academic Affiliation: Chemistry

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  • Using Computational and Statistical Methods as an Aid to Study Environmentally Relevant Organic Molecules

    Creator:
    Dorn, Shelby E.
    Abstract:
    In this report, three studies are presented that utilize computations to predict transformations, identities, and properties of environmental organic molecules. Each study shows how computations can lead to models of chemical behavior. The importance of this research is rooted in the need for understanding how human behavior and health intersect...
    Resource Type:
    Masters Thesis
    Full Text:
    University in the Netherlands, as well as Dr. Jesse H. Kroll at MIT contributed to the experimental

  • Novel ternary graphite intercalation compounds of alkali metal cations and amines

    Creator:
    Maluangont, Tosapol
    Abstract:
    Novel ternary graphite intercalation compounds (GICs) of alkali metal cations and a wide variety of amines have been synthesized by one-pot chemical syntheses. Alkali metals studied includes Li, Na and K. The families of amines employed are nalkylamines, branched alkylamines, and different structural isomers of diamines and polyamines. Intragallery structures...
    Resource Type:
    Dissertation
    Full Text:
    …………………………………...111 5.3 PXRD patterns of Li-EN-GICs: (a) stage 2 as prepared; (b) after 3 h and (c) 6 h

  • Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

    Creator:
    Mahapatra, Subham
    Abstract:
    More than 30 members of the diverse amphidinolide family of biologically active macrolides have been isolated over last three decades. From this family, amphidinolides C and F stand among the most complex and densely functionalized affiliates. Recently, we have accomplished the first total synthesis of amphidinolide F. The all-carbon framework...
    Resource Type:
    Dissertation
    Full Text:
    efforts resulted in the synthesis of several amphidinolides including amphidinolides A,5 B,6 E,7 G and H

  • Graphite intercalation compounds containing tetra-n-alkylammonium cations

    Creator:
    Sirisaksoontorn, Weekit
    Abstract:
    Novel donor-type graphite intercalation compounds (GICs) containing tetra-n-alkylammonium (TAA) cations have been synthesized by using both ion-exchange and electrochemical methods. Structural and compositional data of the resulting TAA-GICs are investigated by using powder X-ray diffraction (PXRD), one-dimensional electron density calculations, thermogravimetric and elemental analyses, and capillary zone electrophoresis (CZE). A...
    Resource Type:
    Dissertation
    Full Text:
    water at 50°C for 72 h

  • Studies on the biosynthesis of the streptolidine moiety of streptothricin F

    Creator:
    Wityak, John
    Abstract:
    The loss of all deuterium labels from previous feedings of [2-²H]-, [3,3-²H₂]-, and [2,3,3-²H₃]arginines had indicated the possible intermediacy of β-hydroxy- and β-ketoarginine (30 and 31, respectively) in the biosynthesis of the streptolidine portion of streptothricin F (la). In order to confirm or refute this evidence, D,L-[2,3,3,5,5-²H₅]- arginine (32) was...
    Resource Type:
    Dissertation
    Full Text:
    roseothricin (H-277) S. roseochromogenes F,D 9 pleocidin S. lavendulae 272 F,E,D,(C,B) 10 geomycin S

  • Biosynthesis of blasticidin S : mechanistic and stereochemical investigations

    Creator:
    Prabhakaran, P. C.
    Abstract:
    Feeding of [3-¹³C, 2-¹⁵N]arginine, 38a, unequivocally established that the β- arginine moiety of blasticidin S, 1, was formed from α-arginine by an intramolecular migration of the α-amino group to the β- position. Further feedings using chirally deuteriated arginines 38e and 38f revealed that the aminomutase process occurred with inversion of...
    Resource Type:
    Dissertation
    Full Text:
    11 in which deuterium from H-2 and H-3 had been retained at H-6 and H-7, respectively. This

  • Asymmetric synthesis of cyclopropanes via a "zipper reaction"

    Creator:
    Lincoln, Christopher M.
    Abstract:
    The rearrangement of a homoallyl cation to a cyclopropylcarbinyl cation is thought to play a role in the biogenesis of a variety of cyclopropane-containing natural products,¹ a hypothesis which has previously led to the design of successful biomimetic syntheses of several natural products.² The strategy underlying this approach to cyclopropane...
    Resource Type:
    Dissertation
    Full Text:
    ), neohalicholactone (189), and the solandelactones A-H (190-197) constructed around a trans- cyclopropane core is

  • Preparation and Properties of Porous Carbon Materials

    Creator:
    Xing, Zhenyu
    Abstract:
    Porous carbon is indispensable in modern technology applications. It is used for energy storage, gas separation, water purification, catalyst support, and chromatography. The diversity of its applications stems from its unique properties, including high specific surface area, tunable pore volume, and chemical stability. Specifically, the large surface area provides high...
    Resource Type:
    Dissertation
    Full Text:
    ) Graphite, (c) Lonsdaleite, (d) Graphene, (e) Carbon nanotube, (f) C60 Fullerene, (g) Graphyne, (h

  • Investigation of Chain Extension Approaches for the Stereoselective Reagent-Controlled Synthesis of alpha-Heteroatom Substituted Alkyl Boronic Esters

    Creator:
    Barsamian, Adam L.
    Abstract:
    Two distinct strategies were explored for the enantioselective synthesis of α-heteroatom substituted alkyl boronic esters by stereoselective reagent-controlled homologation using transient chiral carbenoid reagents CHYMX (Y = heteroatom, X = nucleofuge, M = electrofuge). In the first case, a stereospecific reagent-controlled homologation (sStReCH) approach to α-alkoxyalkylboronates using α-metalated S,O- and...
    Resource Type:
    Dissertation
    Full Text:
    (≤ 2.5 h, at –78 °C) stereodefined α-magnesiated S,O-acetals 103 that incorporated D-atoms in a

  • Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

    Creator:
    Huang, Lin
    Abstract:
    Oxidative stress is defined as an imbalance that favors the production of reactive oxygen species (ROS) over an organism's antioxidant defense. ROS have the ability to damage, either directly or indirectly, biomolecules including DNA, proteins, carbohydrates, and lipids. Various pathological conditions and environmental and chronic diseases have been associated with...
    Resource Type:
    Dissertation
    Full Text:
    tested for hippocampus-dependent contextual fear memory 24 h post-irradiation. Under these experimental