An on-line trace enrichment (TE) system, based on high pressure
liquid chromatogroaphy (HPLC) and flame atomic absorption (AA), has
been developed for trace metal analysis. The sample is pumped through
a column filled with a cation exchange resin which traps metal ions.
The ions are subsequently stripped from the column...
Oxidative stress is recognized as an important underlying factor in the
pathogenesis of many degenerative diseases as well as normal senescence. The
free radicals, reactive oxygen species (ROS) and electrophiles produced during
oxidative stress are capable of modifying nucleic acids, lipids and proteins. There
are a variety of oxidative modifications...
Oxidative stress is defined as an imbalance that favors the production of reactive oxygen species (ROS) over an organism's antioxidant defense. ROS have the ability to damage, either directly or indirectly, biomolecules including DNA, proteins, carbohydrates, and lipids. Various pathological conditions and environmental and chronic diseases have been associated with...
Dysfunction of mitochondria has been linked to aging and the pathogenesis of many degenerative diseases. Aside from their primary function in energy production, mitochondria are considered as a major source and target of reactive oxygen and nitrogen species (ROS/RNS) in cells as well. The mitochondrial thiol proteome is a subset...
This work investigates the effect of cation substitution on the properties of the lead-free, solid solution (Na₀.₅Bi₀.₅)TiO₃-BaTiO₃ (NBT-BT). Substitution into NBT-BT increases disorder and increases the relaxor ferroelectric properties. These relaxor ferroelectric materials show large piezoelectric strains that can be utilized in actuator applications. Ceramic samples were prepared using standard...
In this dissertation, excited state proton transfer (ESPT) and its inhibition in solution and protein environments are revealed using both femtosecond transient absorption (fs-TA) spectroscopy and femtosecond stimulated Raman spectroscopy (FSRS). Using a tunable Raman pump to enhance transient vibrational features of the photoacidic chromophore HPTS in methanol and methanol...