Index Catalog // ScholarsArchive@OSU

Biochemical Studies of Pactamycin Biosynthesis in Streptomyces pactum

Creator:: Eida, Auday
Abstract:: Ribomimetic natural products have long been known for their important biological activities. Structurally, they contain a densely functionalized cyclopentane unit that resembles ribose. Pactamycin, the prominent member of this class of natural products, is a potent protein synthesis inhibitor produced by the soil bacterium Streptomyces pactum. In pactamycin, the aminocyclopentitol...
Resource Type:: Dissertation
Full Text:: members: Dr. Kerry McPhail, Dr. Benjamin Philmus, Dr. Jane Ishmael, and Dr. Daniel Rocky for their

Mass Spectrometry-based Analysis of Superwarfarins and their Metabolites and the Investigation of Novel Treatments for Poisoned Victims

Creator:: Nosal, Daniel Grzegorz
Abstract:: Superwarfarins are anticoagulant rodenticides that are 100 times more potent and 15 times more persistent than warfarin. They have been used since the 1980s and cause over 10,000 cases of accidental and intentional poisonings per year. Apart from inducing uncontrollable bleeding, by inhibiting the vitamin K cycle, superwarfarins can disrupt...
Resource Type:: Dissertation
Full Text:: from my graduate committee, Dr. Aleksandra Sikora, Dr. Benjamin Philmus, Dr. Kerry McPhail and Dr

Characterization and Validation of Neisseria gonorrhoeae Proteins GmhAGC and NGO1985 as Molecular Targets for Development of Novel Anti-gonorrhea Therapeutic Interventions

Creator:: Wierzbicki, Igor H.
Abstract:: The sexually transmitted disease gonorrhea, caused by the Gram-negative bacterium and obligate human pathogen Neisseria gonorrhoeae, remains a significant health and economic burden worldwide. In the absence of a protective vaccine, antimicrobial agents are the only pharmacological intervention for patients with gonorrhea. However, due to the remarkable ability of gonococcus...
Resource Type:: Dissertation
Full Text:: and help with all of the overwhelming paper work; Dr. McPhail for being part of my graduate

Characterization of the Mechanistic Basis for the Cytotoxic Activity of Select Macrocyclic Natural Products against Glioblastoma Cells

Creator:: Serrill, Jeffrey D.
Abstract:: Natural products from both terrestrial and marine sources represent a significant source of novel drug leads, and have previously been developed into clinically-approved agents for the treatment of various human diseases. This work represents the biological characterization of the mechanistic basis for activity of several natural product structures in models...
Resource Type:: Dissertation
Full Text:: academics. I would like to thank Dr. Kerry McPhail for acting as an active, supportive collaborator, and

Biosynthesis and modification of the antibiotic enduracidin

Creator:: Goebel, Neal C.
Abstract:: The continued propagation of antibiotic resistance requires the development of new therapeutics. The lipopeptide antibiotic enduracidin has demonstrated high activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. In addition to a lack of cross-resistance with existing antibiotic classes, enduracidin has no known transferrable resistance mechanism. The development of enduracidin as...
Resource Type:: Dissertation
Full Text:: Mahmud. Phil Proteau and Kerry McPhail. It has been a privilege to have worked with you. The advice and

Biological characterization of coibamide A, a marine natural product from a Panamanian cyanobacterium

Creator:: Hau, Andrew M.
Abstract:: Coibamide A is a methyl-stabilized cyclic depsipeptide with a lariat side chain that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups program based in Panama. Previous testing of this potent and selective growth-inhibitory agent in the National Cancer Institute (NCI) in vitro 60 human...
Resource Type:: Dissertation
Full Text:: . Proteau and Kerry L. McPhail. TABLE OF CONTENTS Page CHAPTER ONE: GENERAL INTRODUCTION

Detection, biosynthesis, and structural investigations of naturally occurring alkynes and other microbial metabolites

Creator:: Back, Daniel C.
Abstract:: Natural products have long been an important source of resources for humans. Many of these compounds possess unique chemical structures and potent biological properties. By targeting natural products with specific chemical properties, we can gain a better understanding of the roles these compounds play in the environment and their interactions...
Resource Type:: Dissertation
Full Text:: . Kerry McPhail and Dr. Aleksandra Sikora, I am thankful for all of the conversations we have shared and

Studies on the ecological functions of the antidiabetic drugs acarbose

Creator:: Tanoeyadi, Samuel
Abstract:: Natural products (a.k.a. secondary metabolites) are produced by living organisms that are not essential for their growth, development, or reproduction, but may play a role in their survival or adaptability in nature. Many secondary metabolites isolated from plants and microbes have found use as molecular probes, drug leads, or medicine...
Resource Type:: Masters Thesis
Full Text:: through my master’s thesis project. I want to also thank all my committee members, Dr. Kerry McPhail, Dr

Non-viral Vectors for Ocular Gene Delivery

Creator:: Herrera-Barerra, Marco, F.
Abstract:: Nucleic acid therapeutics has cemented itself as one of the most efficacious and robust avenues for treatment of a wide range of diseases from vaccine development to treatment of liver, retina, cancer applications. Non-viral mediated gene delivery using lipid-based nanoparticle (LNP) carriers has proven its compatibility with addressing unexpected, fast...
Resource Type:: Dissertation

Natural Products as Pharmacological Tools to probe Mitochondrial and Secretory Function in Cancer Cells

Creator:: Wan, Xuemei
Abstract:: Cancer is the second leading cause of death in the United States. To date, over 60% of current anticancer drugs were inspired by the discovery of chemical structure from nature, commonly known as a natural product. This work represents the biological characterization of several marine natural product compounds and their...
Resource Type:: Dissertation
Full Text:: express my gratitude to Dr. Kerry McPhail for being an active and supportive collaborator. I also wish

ScholarsArchive@OSU

Biochemical Studies of Pactamycin Biosynthesis in Streptomyces pactum

Mass Spectrometry-based Analysis of Superwarfarins and their Metabolites and the Investigation of Novel Treatments for Poisoned Victims

Characterization and Validation of Neisseria gonorrhoeae Proteins GmhAGC and NGO1985 as Molecular Targets for Development of Novel Anti-gonorrhea Therapeutic Interventions

Characterization of the Mechanistic Basis for the Cytotoxic Activity of Select Macrocyclic Natural Products against Glioblastoma Cells

Biosynthesis and modification of the antibiotic enduracidin

Biological characterization of coibamide A, a marine natural product from a Panamanian cyanobacterium

Detection, biosynthesis, and structural investigations of naturally occurring alkynes and other microbial metabolites

Studies on the ecological functions of the antidiabetic drugs acarbose

Non-viral Vectors for Ocular Gene Delivery

Natural Products as Pharmacological Tools to probe Mitochondrial and Secretory Function in Cancer Cells

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