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Filtering by: Creator Krishnan, Natraj Academic Affiliation Integrative Biology

The circadian clock gene period extends healthspan in aging Drosophila melanogaster

Creator:

Krishnan, Natraj, Kretzchmar, Doris, Rakshit, Kuntol, Chow, Eileen, and Giebultowicz, Jadwiga M.

Abstract:

There is increasing evidence that aging is affected by biological (circadian) clocks – the internal mechanisms that coordinate daily changes in gene expression, physiological functions and behavior with external day/night cycles. Recent data suggest that disruption of the mammalian circadian clock results in accelerated aging and increased age‐related pathologies such...

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period extends healthspan in aging Drosophila melanogaster Natraj Krishnan1, Doris Kretzschmar2
Effects of Aging on the Molecular Circadian Oscillations in Drosophila

Creator:

Rakshit, Kuntol, Krishnan, Natraj, Guzik, Elzbieta M., Pyza, Elzbieta, and Giebultowicz, Jadwiga M.

Abstract:

Circadian clocks maintain temporal homeostasis by generating daily output rhythms in molecular, cellular, and physiological functions. Output rhythms, such as sleep/wake cycles and hormonal fluctuations, tend to deteriorate during aging in humans, rodents, and fruit flies. However, it is not clear whether this decay is caused by defects in the...

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@science.oregonstate.edu. The current address of Natraj Krishnan is Department of Biochemistry, Molecular Biology