Index Catalog // ScholarsArchive@OSU

Immunohistochemistry Studies of Tumor Necrosis Factor Αlpha and Interferon Gamma Expression in Pseudocapillaria tomentosa Infected and Uninfected Zebrafish

Creator:: Lo, Lalee C.
Abstract:: Tumor necrosis factor alpha (TNF α) and interferon gamma (IFN γ) were initially recognized as inflammatory mediators produced by immune cells in response to infectious agents or foreign material. (1,5) However, over the past decade much research in mammalian species has indicated that these proteins also play key roles in...
Resource Type:: Presentation and Undergraduate Thesis
Full Text:: for the extensive support from my mentor, Jan Marie Spitsbergen for it would not have been possible

Ultrastructural study of spontaneous orocutaneous papillomas of brown bullheads Ictalurus nebulosus

Creator:: Poulet, Frederique M. and Spitsbergen, Jan M.
Abstract:: Eight spontaneous orocutaneous papillomas of adult, wild-caught brown bullheads Ictalurus nebulosus and 4 anatomically matching control tissue samples were examined by electron microscopy. Ultrastructural characteristics of normal and neoplastic Malpighian epithelial cells were compared and neoplastic cells were described. Normal Malpighian epithelial cells of brown bullheads were similar to those...
Resource Type:: Article
Full Text:: bullheads Ictalurus nebulosus Frederique M. Poulet*, Jan M. Spitsbergen Department of Avian and Aquatic

Neoplasia and Neoplasm Associated Lesions in Laboratory Colonies of Zebrafish Emphasizing Key Influences of Diet and Aquaculture System Design

Creator:: Spitsbergen, Jan M., Buhler, Donald R., and Peterson, Tracy S.
Abstract:: During the past decade the zebrafish has emerged as a leading model for mechanistic cancer research due to its sophisticated genetic and genomic resources, its tractability for tissue targeting of transgene expression, its efficiency for forward genetic approaches to cancer model development, and its cost-effectiveness for enhancer and suppressor screens...
Resource Type:: Article
Full Text:: of Diet and Aquaculture System Design 2 Jan M. Spitsbergen, Donald R. Buhler and Tracy S. Peterson

Pathological and Behavioral Manifestations of the “Cayuga Syndrome,” a Thiamine Deficiency in Larval Landlocked Atlantic Salmon

Creator:: Fisher, Jeffrey P., Spitsbergen, Jan M., Iamonte, Tina, Little, Edward E., and Delonay, Aaron
Abstract:: The “Cayuga syndrome” is a maternally transmitted, naturally occurring thiamine deficiency that causes 100% mortality of larval landlocked Atlantic salmon Salmo salar in several of New York's Finger Lakes, Results of multiyear studies to qualify and quantify the neurobehavioral and gross pathological signs of this condition are described, Affected sac...
Resource Type:: Article
Full Text:: Larval Landlocked Atlantic Salmon JEFFREY P. FISHER, 1,2 JAN M. SPITSBERGEN,1,3 AND TINA IAMONTE

Naturally Occurring Thiamine Deficiency Causing Reproductive Failure in Finger Lakes Atlantic Salmon and Great Lakes Lake Trout

Creator:: Fisher, Jeffrey P., Fitzsimons, John D., Combs, Gerald F. Jr., and Spitsbergen, Jan M.
Abstract:: A maternally transmitted, noninfectious disease known as the Cayuga syndrome caused 100% mortality in larval offspring of wild-caught landlocked Atlantic salmon Salmo salar from several of New York's Finger Lakes. Survival of lake trout Salvelinus namaycush from Lakes Erie and Ontario was also impaired, but not until yolk absorption was...
Resource Type:: Article

Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish

Creator:: Ju, Bensheng, Spitsbergen, Jan, Eden, Christopher J., Taylor, Michael R., and Chen, Wenbiao
Abstract:: The zebrafish has become an important model for cancer research. Several cancer models have been established by transgenic expression of human or mouse oncogenes in zebrafish. Since it is amenable to efficient transgenesis, zebrafish have immense potential to be used for studying interaction of oncogenes and pathways at the organismal...
Resource Type:: Article

Transgenic expression of Walleye dermal sarcoma virus rv-cyclin gene in zebrafish and its protective effect on liver-tumor development after carcinogen treatment

Creator:: Zhan, Huiqing, Spitsbergen, Jan, Qing, Wei, Wu, Yi Lian, Paul, Thomas A., Casey, James W., and Gong, Zhiyuan
Abstract:: A retrovirus homologue gene of cellular cyclin D₁, walleye dermal sarcoma virus rv-cyclin gene (orf A or rv-cyclin), was expressed in the livers of zebrafish under the control of liver fatty-acid binding protein (lfabp) promoter. To prevent possible fatality caused by over-expression of the oncogene, the GAL4/UAS system was used...
Resource Type:: Article
Full Text:: after carcinogen treatment Huiqing Zhan, 1 Jan Spitsbergen, 2 Wei Qing, 1 Yi Lian Wu, 1

Reproductive Failure of Landlocked Atlantic Salmon from New York's Finger Lakes: Investigations into the Etiology and Epidemiology of the “Cayuga Syndrome”

Creator:: Fisher, Jeffrey P., Spitsbergen, Jan M., Getchell, Rodman, Symula, John, Skea, Jack, Babenzein, Mark, and Chiotti, Thomas
Abstract:: We describe a disease syndrome that afflicts larval, landlocked Atlantic salmon Salmo salar from Cayuga Lake, one of central New York's Finger Lakes. Mortality associated with the “Cayuga syndrome” is 98–100%. Death usually occurs between 650 and 850 centigrade degree-days after fertilization, approximately 2–4 weeks before yolk resorption is complete....
Resource Type:: Article
Full Text:: Etiology and Epidemiology of the "Cayuga Syndrome" JEFFREY P FISHER,1 JAN M . SPITSBERGEN, AND RODMAN

An inducible kras[superscript v]¹² transgenic zebrafish model for liver tumorigenesis and chemical drug screening

Creator:: Nguyen, Anh Tuan, Emelyanov, Alexander, Koh, Chor Hui Vivien, Spitsbergen, Jan M., Parinov, Serguei, and Gong, Zhiyuan
Abstract:: Because Ras signaling is frequently activated by major hepatocellular carcinoma etiological factors, a transgenic zebrafish constitutively expressing the kras(V12) oncogene in the liver was previously generated by our laboratory. Although this model depicted and uncovered the conservation between zebrafish and human liver tumorigenesis, the low tumor incidence and early mortality...
Resource Type:: Article
Full Text:: Nguyen1,2, Alexander Emelyanov2,*, Chor Hui Vivien Koh1,*, Jan M. Spitsbergen3, Serguei Parinov2,‡ and

A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors

Creator:: Li, Zhen, Zheng, Weiling, Wang, Zhengyuan, Zeng, Zhiqiang, Zhan, Huiqing, Li, Caixia, Zhou, Li, Yan, Chuan, Spitsbergen, Jan M., and Gong, Zhiyuan
Abstract:: Myc is a pleiotropic transcription factor that is involved in many cellular activities relevant to carcinogenesis, including hepatocarcinogenesis. The zebrafish has been increasingly used to model human diseases and it is particularly valuable in helping to identify common and conserved molecular mechanisms in vertebrates. Here we generated a liver tumor...
Resource Type:: Article
Full Text:: Zhan1, Caixia Li1, Li Zhou1, Chuan Yan1, Jan M. Spitsbergen2 and Zhiyuan Gong1,‡ RESEARCH ARTICLE D

ScholarsArchive@OSU

Immunohistochemistry Studies of Tumor Necrosis Factor Αlpha and Interferon Gamma Expression in Pseudocapillaria tomentosa Infected and Uninfected Zebrafish

Ultrastructural study of spontaneous orocutaneous papillomas of brown bullheads Ictalurus nebulosus

Neoplasia and Neoplasm Associated Lesions in Laboratory Colonies of Zebrafish Emphasizing Key Influences of Diet and Aquaculture System Design

Pathological and Behavioral Manifestations of the “Cayuga Syndrome,” a Thiamine Deficiency in Larval Landlocked Atlantic Salmon

Naturally Occurring Thiamine Deficiency Causing Reproductive Failure in Finger Lakes Atlantic Salmon and Great Lakes Lake Trout

Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish

Transgenic expression of Walleye dermal sarcoma virus rv-cyclin gene in zebrafish and its protective effect on liver-tumor development after carcinogen treatment

Reproductive Failure of Landlocked Atlantic Salmon from New York's Finger Lakes: Investigations into the Etiology and Epidemiology of the “Cayuga Syndrome”

An inducible kras[superscript v]¹² transgenic zebrafish model for liver tumorigenesis and chemical drug screening

A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors

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