Index Catalog // ScholarsArchive@OSU

Development of Hot-melt Pan-coating, Application to Sustained-release Capsules and Tamper Resistant-coating. 2) Formulation of Verapamil HCl and Diltiazem HCl Semisolid Matrix Capsules. 3) Novel Sustained Release Tablet of Glipizide: Compression of Coated Drug Beads, Formulation, Dissolution, and Convolution. 4) Verapamil Sustained Release: New Formulation and Convolution

Creator:: Nguyen, Chien Ngoc
Abstract:: Hot-melt pan-coating, which is a novel coating method and takes 2-3 hours for 300 mg coating weight gain per capsule and tamper-resistant coating, which takes 30 minutes, is much faster than tedious sugar coating and allows greater coating weight gains in shorter times than spray-melt coating. Although hot-melt pan coating...
Resource Type:: Dissertation
Full Text:: ……………………………………....................... 89 TABLE OF CONTENTS (Continued) Page CHAPTER 4 NOVEL SUSTAINED-RELEASE TABLET OF

The study of pharmacokinetics in a clinical environment

Creator:: Tse, Sunny
Abstract:: This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
Resource Type:: Dissertation
Full Text:: dose of 125mg on day 1, and 80mg daily until 4 days after the hematopoietic stem cell transplant. In

In vitro and in vivo testing of a gastric retention device : development and evaluation of a new colonic delivery system

Creator:: Ahmed, Iman Saad
Abstract:: This thesis describes evaluation of a gastric retention device (GRD) developed at Oregon State University. The device was originally fabricated from Xanthan gum and Locust bean gum. A modified gastric retention device containing other additives was developed and investigated in this work. The modified device was evaluated in vitro for...
Resource Type:: Dissertation
Full Text:: Doctor of Philosophy in Pharmacy presented on September 4, 2002. Title: (1) In Vitro and In Vivo

Pharmacokinetic/pharmacodynamic modeling/simulation and novel gastric retention formulation

Creator:: Kwon, Hyojong
Abstract:: This dissertation describes formulation of a gastric retention device (GRD) and sustained release (SR) hydrochlorothiazide beads at Oregon State University. Formulation condition and amounts of excipients had significant influence on characteristic of the GRD. The GRD containing SR hydrochlorothiazide beads was employed to assess bioavailability/bioequivalency study in healthy subjects. An...
Resource Type:: Dissertation
Full Text:: Retention Device and Sustained Release Hydrochlorothiazide Beads 3 Abstract 4 Introduction 6 Materials

Pharmacokinetic investigation of a potential drug interaction : aminophylline and prednisone

Creator:: Anderson, John L.
Resource Type:: Masters Thesis
Full Text:: correlation examplefied by prednisone. J Pharmacokinet Biopharm. 1976; 4:173-81. 23. Brooks SM, Werk EE

Antimicrobial vaginal dosage forms employing Dimethyl Fumarate or propionic acid

Creator:: Sahajwalla, Chandrahas G.
Abstract:: Propionic acid, live Propionibacterium shermanii, and Dimethyl Fumarate (DMF) were tested for their stimulatory or inhibitory efects on yeast, bacteria, and molds. The amount of propionic acid required for inhibition of molds was strain specific and equal to or less than that required for inhibition of the yeasts. Live P....
Resource Type:: Masters Thesis
Full Text:: in human plasma maintained at 37°C. 4. Plots obtained from pooling the data of DMF degradation

Clinical pharmacokinetic simulation/modeling as a tool for therapeutic drug monitoring and dose adjustment in special patient populations

Creator:: Mohamed, Osama H.
Abstract:: This dissertation describes how to apply pharmacokinetic simulations and modeling in a clinical setting to monitor and adjust drug dosing in special patient populations. Pharmacokinetic simulations were used to investigate efficacy and risk of drug toxicity of a new dosing regimen for aminoglycoside antibiotics when administered to renal failure patients....
Resource Type:: Dissertation
Full Text:: Doctor of Philosophy dissertation of Osama H. Mohamed presented on August 6. 2004. APPROVED: // / 4

Preparing sustained release dosage forms of nifedipine by hot-melt coating method

Creator:: Le, Hang Thi
Abstract:: A nifedipine sustained release dosage form was prepared by using hot-melt batch coating. Substrates are sugar beads, mesh size 30-35. Stearic acid, Acid Triglyceride, and carnauba wax were coating agents used to make single layer coated beads and multiple layer coated beads containing nifedipine. Dissolution of nifedipine from the beads...
Resource Type:: Masters Thesis
Full Text:: ......................................... 1 Sustained release of nifedipine ............................. 4 CHAPTER 2 LITERATURE REVIEW 5

New product formulations, pharmacokinetics and bioavailability of dyphylline

Creator:: Chang, Shyi-Feu
Abstract:: Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage forms are presented in chapter one of this thesis. In vivo single dose and multiple dose studies of two sustained-release formulations as well as one conventional dyphylline formulation are described in chapter two. The pharmacokinetics of dyphylline following...
Resource Type:: Dissertation
Full Text:: - pretreatment rotating basket dissolution methed (75 rpm) 1.38 % Dyphylline released from dyphylline 89

A novel self-sealing chewable sustained release tablet of acetaminophen ; Development and evaluation of novel itraconazole oral formulations ; A novel zero order release matrix tablet

Creator:: Rakkanka, Vipaporn
Abstract:: This thesis describes evaluation of a novel self-sealing chewable sustained release tablet that can maintain controlled release of drug regardless of compaction, crushing, or chewing. The new formulation contains polyethylene oxide which produces a sealant effect for cracks produced in the polymer coating during compaction. Dissolution studies were conducted and...
Resource Type:: Dissertation
Full Text:: EVALUATION OF A NOVEL SELF-SEALING CHEWABLE SUSTAINED RELEASE TABLET OF ACETAM[NOPHEN ............... 4

ScholarsArchive@OSU

The study of pharmacokinetics in a clinical environment

In vitro and in vivo testing of a gastric retention device : development and evaluation of a new colonic delivery system

Pharmacokinetic/pharmacodynamic modeling/simulation and novel gastric retention formulation

Pharmacokinetic investigation of a potential drug interaction : aminophylline and prednisone

Antimicrobial vaginal dosage forms employing Dimethyl Fumarate or propionic acid

Clinical pharmacokinetic simulation/modeling as a tool for therapeutic drug monitoring and dose adjustment in special patient populations

Preparing sustained release dosage forms of nifedipine by hot-melt coating method

New product formulations, pharmacokinetics and bioavailability of dyphylline

A novel self-sealing chewable sustained release tablet of acetaminophen ; Development and evaluation of novel itraconazole oral formulations ; A novel zero order release matrix tablet

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Creator

Date

Decade

Degree Field

Degree Level

Degree Name

File Format

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search