The marine cyanobacterium Lyngbya majuscula has proven to be extraordinarily rich in bioactive secondary metabolites. This dissertation describes the chemistry of L. majuscula collected from Grenada, Fiji and Papua New Guinea, and the biosyntheses of two L. majuscula metabolites, curacin A and barbamide.
The chemical studies with a Grenada collection...
Farlowia mollis is a marine red alga that grows in the
intertidal region along the coast of Oregon. We began studying
the chemistry of this alga after a survey of Oregon seaweeds
revealed possibly interesting chemistry and antimicrobial activity
in its crude organic extract.
Over the past three years the...
I have participated in a drug discovery program designed to screen marine algae for
inhibitors of cancer-related enzymes, antitumor compounds, antiinflammatory substances,
and other agents of potential pharmaceutical utility. Over 1,500 lipid and aqueous extracts
of marine plants and animals were surveyed for biomedical potential. Assays designed to
screen extracts...