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Filtering by: Creator Kioussi, Chrissa Advisor Ishmael, Jane E.

Investigation of autophagy-assisted cell death in response to the cancer cell toxin coibamide A

Creator:

Tan, Michelle

Abstract:

Autophagy, a homeostatic degradation pathway, has a role in promoting cell survival under stress conditions, but can also promote cell death under conditions of sustained stress. This project investigates the cytotoxic potential of coibamide A and other natural products in autophagy-deficient and wild-type mouse embryonic fibroblasts (MEFs). Wild-type MEFs were...

Resource Type:

Honors College Thesis

Full Text:

Sciences Chrissa Kioussi, Committee Member, representing Pharmaceutical Sciences
Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Creator:

Bajaj, Gaurav

Abstract:

EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...

Resource Type:

Dissertation

Full Text:

did the microscopy and Dr. Chrissa Kioussi helped in making figures. All experiments in chapter 3
Natural Products as Pharmacological Tools to probe Mitochondrial and Secretory Function in Cancer Cells

Creator:

Wan, Xuemei

Abstract:

Cancer is the second leading cause of death in the United States. To date, over 60% of current anticancer drugs were inspired by the discovery of chemical structure from nature, commonly known as a natural product. This work represents the biological characterization of several marine natural product compounds and their...

Resource Type:

Dissertation

Full Text:

would like to thank Dr. Arup Indra, Dr. Chrissa Kioussi and their laboratory members for their