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Creator:: Kaufman, Stuart Neil
Abstract:: The temporal relationships among selected correlates of hepatocellular damage were investigated in cordotomized, hypothermic rats intoxicated with carbon tetrachloride (CC1₄). Rats were spinally transected between C6 and C7 and allowed to become hypothermic. CC1₄ (1.25 ml/kg ip) was administered as a 1:1 solution in corn oil. Plasma alanine aminotransferase (ALT)...
Resource Type:: Masters Thesis
Full Text:: degree of Master of Science in Pharmacy (Toxicology) presented on March 12, 1979 Title: THE EFFECT OF

Creator:: Svec, Alan Lee
Abstract:: The nephrotoxicities of the aminoglycoside antibiotics tobramycin (TBM) and netilmicin (NTM) were studied in rainbow trout (Salmo gairdneri) to determine the usefulness of salmonids as a sensitive animal mode for investigating the nephrotoxic potential of these agents. Logit analysis revealed that 8-12 day i.p. LD 50's in rainbow trout for...
Resource Type:: Masters Thesis
Full Text:: gairdneri) AN ABSTRACT OF THE THESIS OF Alan Lee Svec for the degree of Master of Science in Pharmacy

Creator:: Acholonu, Wilfred W.
Abstract:: The effects of L-ascorbic acid, thiamine HC1, or L-cysteine on acetaldehyde blood levels and disposition were investigated in acetaldehyde- treated rats. Rats were treated with ascorbic acid (2 mmoles/kg), thiamine (0.24 mmole/kg), or cysteine (2 mmoles/kg) one hour before the administration of acetaldehyde (6 mmoles/kg). The results show that each...
Resource Type:: Masters Thesis
Full Text:: . Acholonu, Jr. for the degree of Master of Science in Pharmacy presented on September 28, 1983 . Title

Creator:: Hoyt, Dale G.
Abstract:: BCNU caused severe cholestasis in rats after a single intraperitoneal injection. The cholestasis was characterized by a selective reduction of the bile salt independent bile flow to 11% of control. Decreased food or water consumption by the treated rats apparently did not contribute to cholestasis. Measurements of plasma Na⁺ and...
Resource Type:: Masters Thesis
Full Text:: Master of Science in Pharmacy presented on April 13, 1984 . Title: Characterization of Cholestasis

Creator:: Jarvi, Eric J.
Abstract:: Male Sprague Dawley rats received a single intraperitoneal dose of BCNU in experiments designed to measure biochemical changes associated with the pulmonary toxicity described for this agent. Changes in serum and lung lavage angiotensin converting enzyme (ACE) activity were measured to detect changes in pulmonary endothelial cell integrity. Alpha-1-proteinase inhibitor...
Resource Type:: Dissertation
Full Text:: toxicity An Abstract of the Thesis of Eric J. Jarvi for the degree of Doctor of Philosophy in Pharmacy

Creator:: Stolzenbach, James Carlson, 1954-
Abstract:: Rats were given single i.p. injections of BCNU to investigate changes in hepatic cytochrome P-450 content and specific activity in male rats. Microsomal P-450 levels were unchanged from 6 hours to 7 days after BCNU treatment but by day 21 they had decreased 45%. Ethylmorphine N-demethylase activity (nm product x...
Resource Type:: Dissertation
Full Text:: James Carlson Stolzenbach for the degree of Doctor of Philosophy in Pharmacy presented on June 20

Creator:: Dalich, George M.
Abstract:: The hepatotoxicity of CB was studied in the Sprague-Dawley rat and rainbow trout. In rats, an ip dosage of 9.8 mmol/kg CB (~̲ LD10) produced evidence of liver toxicity over a 72 hr time course. Sulfobromophthalein (BSP) retention maximized 3-16 hr post treatment and normalized after 72 hr whereas plasma...
Resource Type:: Dissertation
Full Text:: Pharmacy presented on May 29, 1984 ' Title: Hepatotoxicity of Monochlorobenzene in Rats and Rainbow Trout

Creator:: Hoyt, Dale G.
Abstract:: Previous investigation showed that 20 mg/kg BCNU caused inhibition of sulfobromophthalein (BSP) excretion and inhibited bile salt independent bile flow (BSIF) in rats by 48 h after treatment (Hoyt, 1984). The present investigation demonstrated that BCNU inhibited the canalicular step in the excretion of BSP. This was indicated by the...
Resource Type:: Dissertation
Full Text:: Dale G. Hoyt for the degree of Doctor of Philosophy in Pharmacy presented on July 11, 1985. Title

Creator:: Rawson, Cathleen L.
Resource Type:: Dissertation
Full Text:: . Rawson for the degree of Doctor of Philosophy in Pharmacy (Pharmacology) presented on July 10, 1985

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