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Creator:: Zhu, Chenxi
Abstract:: Exploring bioactive natural products has contributed largely to clinically approved drugs we have been using over the last 100 years. Especially among the anti-infective drugs, around 70% of currently used antibiotics were discovered or derived from microbial secondary metabolites, among them compounds like vancomycin, chloramphenicol, and erythromycin. Facing the unavoidable...
Resource Type:: Dissertation
Full Text:: approved: _____________________________________________________ Sandra Loesgen Exploring bioactive

Creator:: González-Montiel, Gisela Abigail
Abstract:: Fungi have long been used for discovery of new chemical scaffolds. In the clinical setting, the fungal natural products penicillin, statins, and cyclosporine have revolutionized medicine to treat diseases and infections. In the environment, fungal natural products have been used as herbicides, fungicides, and insecticides to protect crops, livestock, and...
Resource Type:: Masters Thesis
Full Text:: : ______________________________________________________ Sandra Loesgen Fungi have long been used for discovery of new chemical scaffolds. In the

Creator:: Li, Jinming
Abstract:: Mandelalide A has attracted considerable interest from the synthetic community due to its intriguing structure and important cytotoxic activity. Madeirolide A, a structurally related macrolide, shows promising antifungal activity but no appreciable anticancer activity. This dissertation describes synthetic studies toward mandelalide A, madeirolide A and their hybrid structures. Part I...
Resource Type:: Dissertation
Full Text:: Blakemore, Professor Sandra Loesgen, Professor Deidre Johns, Professor Yun-Shik Lee and Professor David Ji

Creator:: Saha, Mrinmoy
Abstract:: Lycopodium alkaloids have shown widespread and noteworthy biological activity, consisting of over 250 known natural products. Moreover, their structural complexity and diversity have attracted considerable attention from numerous laboratories including our own. Recently, we have developed a unified approach that would provides access to numerous, previously unprepared C₁₀-functionalized lycopodium alkaloids....
Resource Type:: Dissertation
Full Text:: Sinica 2010, 31, 649-664. 2. (a) Zhang, Z., Wang, X.; Chen, Q.; Shu, L.; Wang, J.; Shan, G. Zhonghua

Creator:: Goswami, Subir
Abstract:: The furanyl diterpenoid family of natural products has drawn the attention of both synthetic organic chemists and pharmacologists due to their complex structural architectures and diverse biological activity. Among them, wortmannin has been most extensively studied for biological activities. All these furanyl diterpenoids consist of a highly strained naptha[1,8-bc]furan core,...
Resource Type:: Dissertation
Full Text:: References [1] Wipf, P.; Halter, R. J. Org. Biomol

Creator:: Ju, Xuan
Abstract:: Dearomatization reactions exist broadly in biosynthesis and chemical synthesis. The highly functionalized atoms of arenes can be masked by it aromaticity, and upon dearomatization, those reactive atoms can be readily applied to bond formation and further manipulation. The total synthesis of (–)-cephalotaxine and (–)- homoharringtonine is described via an oxidative...
Resource Type:: Dissertation
Full Text:: .; Boll, M. J. Am. Chem. Soc. 2008, 130, 14050–14051; b) Kung, J. W.; Baumann, S.; Von Bergen, M

Creator:: Li, Xin
Abstract:: This dissertation is separated into two parts according to the two major distinct research projects. In Part I, the full account of synthetic studies toward C10-functionalized lycopodium alkaloids is described. In Part II, the detailed discussion on the exploration of the Pummerer cyclization methodology and its application to the total...
Resource Type:: Dissertation
Full Text:: . Paul Blakemore, Prof. Sandra Loesgen, Prof. Paul Ha-Yeon Cheong, Prof. Xiulei Ji and Prof. Liney

Creator:: Ghosh, Ankan
Abstract:: Part I of this dissertation includes the chronological synthetic background of mandelalide A as well as the synthesis of the C1-C14 glycosylated southern subunit of mandelalide. A key aspect of the synthesis includes a novel silver-catalyzed cyclization (AgCC) of a propargylic benzoate to construct the substituted cis-pyran ring system present...
Resource Type:: Dissertation
Full Text:: extend my thankfulness to Prof. Paul R. Blakemore and Prof. Sandra Loesgen with whom I took most of the

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