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Filtering by: Committee Member Brown, Lyle Date issued sim 2002-06-12

1. Regulation of mouse ribonucleotide reductase by allosteric effector-substrate interplay and hypoxia

Creator:: Chimploy, Korakod
Abstract:: In order to maintain genetic stability in eukaryotes, tight regulation of the relative sizes of deoxyribonucleoside triphosphate (dNTP) levels inside the cell is essential for optimal fidelity of DNA replication. Ribonucleotide reductase (RNR) is the enzyme responsible for proportional production of DNA precursors. Studies on regulation of this enzyme, the...
Resource Type:: Dissertation