Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Creator Cassina, Patricia Creator Beckman, Joseph S.

Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis

Creator:

Trias, Emiliano, Cassina, Patricia, Martínez-Palma, Laura, Moura, Ivan C., Beckman, Joseph S., Hermine, Olivier, Barbeito, Luis, Ibarburu, Sofía, Barreto-Núñez, Romina, Babdor, Joël, Maciel, Thiago T., Guillo, Matthias, Gros, Laurent, Dubreuil, Patrice, and Díaz-Amarilla, Pablo

Abstract:

Background: In the SOD1^G93A mutant rat model of amyotrophic lateral sclerosis (ALS), neuronal death and rapid paralysis progression are associated with the emergence of activated aberrant glial cells that proliferate in the degenerating spinal cord. Whether pharmacological downregulation of such aberrant glial cells will decrease motor neuron death and prolong...

Resource Type:

Article

Full Text:

. Maciel2,3,4,5,6,7, Matthias Guillo2,3,4,5, Laurent Gros8, Patrice Dubreuil7,8,9, Pablo Díaz-Amarilla10, Patricia