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Filtering by: Subject Anti-infective agents -- Structure-activity relationships Remove constraint Subject: Anti-infective agents -- Structure-activity relationships Creator Yu, Yupei Remove constraint Creator: Yu, Yupei

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  • A quantitative structure activity relationships study of antiinfectives based on the nalidixic acid structure

    Creator:
    Yu, Yupei
    Abstract:
    Nalidixic acid and its derivatives act through inhibition of bacterial DNA gyrase activity. Recently there have been a series of papers reporting the antibacterial activity against three different types of bacteria (S. aureus, E. coli and P. aeruginosa) by a series of 1,4-dihydro-4-oxoquinoline (or 1,8-naphthyridine) 3-carboxylic acids. Consistent biological data...
    Resource Type:
    Masters Thesis
    Full Text:
    antibacterial agents. The two most frequently used models in quantitative structure activity relationship are