Background: Osteosarcoma (OSA) is the most common primary bone tumor of dogs and carries a poor prognosis
despite aggressive treatment. An improved understanding of the biology of OSA is critically needed to allow for
development of novel diagnostic, prognostic, and therapeutic tools. The surface-exposed proteome (SEP) of a
cancerous cell...
In this thesis I present the choice calculus, a formal language for representing variation in software and other structured artifacts. The choice calculus is intended to support variation research in a way similar to the lambda calculus in programming language research. Specifically, it provides a simple formal basis for presenting,...
The first part of the dissertation is to evaluate the use of proposed and established equations for area under the plasma concentration versus time (AUC) for molecules undergoing nonlinear Michaelis–Menten pharmacokinetic elimination. The effects of varying Michaelis-Menten parameters, rate of drug absorption, or bioavailability on the predictability of drug exposure...
The purposes of this study were to: 1) determine in what ways incorporating active engagement into a traditional lecture chemistry course contributed to students' science identity and their motivation to learn the science, and 2) determine how the development of a science identity could be measured through the use of...
With the evolving popularity of new computing platforms such as Ultrabooks, Tablets, and Smart Phones, and the shift to multi-core computing, power is now the key performance limiter, a departure from the traditional frequency limitation. As such, increasingly low-power design solutions feature prominently in early architectural and design space exploration...
The variable output of renewables such as wind and solar causes fluctuations of power flow that can adversely affect power system operation, especially at high levels of penetration. The coordination of multiple energy storage solutions can mitigate integration challenges by providing a buffer from variable renewables. This thesis presents the...
Physical activity recognition using accelerometer data is a rapidly emerging field with many real-world applications. Much of the previous work in this area has assumed that the accelerometer data has already been segmented into pure activities, and the activity recognition task has been to classify these segments. In reality, activity...
Development of micro air vehicles has led to a strong interest in the biomechanics of flapping fliers such as bats, birds, and insects, due to their ability to perform extreme unsteady maneuvers and fly in confined spaces. Determining the methods and mechanisms used by these fliers is a valuable source...
Differences in the chemical composition of calcified structures can be used to reveal natal origins, connectivity, metapopulation structure, and reconstruct the environmental history or movement patterns of many marine organisms. Sharks, skates, and rays (elasmobranchs) lack the calcified structures, known as otoliths, that are typically used for geochemical studies of...
A previous study conducted in our laboratory demonstrated the critical role that retronasal odors play in vegetable liking and disliking. It remains unclear, however, why some individuals like certain vegetable odors, while others do not. A possible explanation is that some individuals have learned to like the odor of a...