We investigated DNA methylomes of pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profiles. Epigenetic alteration of B-ALLs occurred in two tracks: de novo methylation of small functional compartments and demethylation of large intercompartmental backbones. The deviations were exaggerated in lamina-associated...
Meta-analyses of field studies have shown that biomass, density, species richness, and size of organisms protected by no-take marine reserves generally increase over time. The magnitude and timing of changes in these response variables, however, vary greatly and depend upon the taxonomic groups protected, size and type of reserve, oceanographic...
Tourism presents a significant challenge for island economies in the Global South attempting to improve local standards of living. Due to limited resources and often low education levels of island residents, tourism development frequently becomes a tool for foreign investors to profit while local people continue to work low-income jobs....
Architects and engineers are two key types of design professionals who influence the use of wood products in construction. Eighty to ninety percent by volume of all residential structures in the U.S. are wood (Gupta, 2005). In 2010, the non-residential market was made up by 10% wood, 60% steel and...
Pardoxes in voting has been an interest of voting theorists since the 1800's when Condorcet demonstrated the key example of a voting paradox: voters with individually transitive rankings produce an election outcome which is not transitive. With Arrow's Impossibility Theorem, the hope of finding a fair voting method which accurately...
The objective of the research presented herein is to elucidate the effect of traps in determining amorphous oxide semiconductor thin-film transistor (AOS TFT) performance using modeling and characterization. A novel method is proposed to extract the interface state distribution from a TFT transfer curve. Analysis of zinc-indium oxide (ZIO), zinc-tin...