Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motor neurons in the motor cortex and spinal cord. Recent evidence suggests that the purine receptor P2X7 (P2X7R) plays a central role in the pathology of ALS. Previous research indicates that P2X7R activation by oxidatively modified heat shock protein 90...
Antibiotic resistance is an increasing problem in many species of bacteria today, with pathogens an important focus. Fecal contamination of shellfish is already a concern due to potential pathogens. This report examines the possibility of resistance gene transfer between microbes, due to fecal bacteria, within the oyster. In this study,...
Abstract
Haptoglobin is an acute phase protein that is elevated in response to tissue damage and infections in dairy cows. The objectives of this study were to evaluate whether serum haptoglobin concentrations in the first week after calving can indicate disease status and severity, and whether haptoglobin concentrations are elevated...
Farmers rely almost exclusively on the imported European honeybee (Apis mellifera L.) for fruit and vegetable crop pollination services. The recent decline in honeybee health has underscored the danger of relying on a single species to provide vital services. Increasing pollinator biodiversity with native bees may provide biological insurance against...
Agricultural areas can be inhospitable to the attraction and maintenance of beneficial insects like natural enemies and pollinators and this can result in a decrease in the ecosystem services of pollination and pest control that these insects supply. If habitat can be created and maintained on-farm, an increase in the...
Background: Uterine inflammation (e.g., endometritis) causes negative economic effects in the beef industry by reducing reproductive performance. Current treatments for endometritis in beef cattle involve hormones and antibiotics, which can be expensive and are often ineffective. The endometrial immune response regulates the release of cytokines and chemokines in response to...
Endophytes, foliage inhabiting fungi, are an unexplored source of fungal biodiversity and a potential resource for the production of bioactive natural products. In this research, leaf tissues from the species Arbutus menziesii, Rhododendron macrophyllum and the genus, Ilex and Salix were collected for the isolation of endophytic fungi. Fungal extracts...
Polycyclic aromatic hydrocarbons (PAHs) are a class of contaminants ubiquitous in the environment and result from the incomplete combustion of fossil fuels. Many PAHs have been identified as procarcinogenic, and are metabolized to form DNA adducts; however, other mechanisms also may contribute to toxicity and help explain differences in toxicity...
Understanding the mechanisms through which stem cells self-renew is important for the development of new therapies to repair and restore damaged tissue. This research explores possible mechanisms of telomere mimic action and seeks to validate a new assay for evaluating telomere binding antagonists and studying the effects of telomere binding...
Organophosphate insecticides may produce sublethal, adverse effects on salmonid
growth, reproduction, maturation, swimming, and feeding. Chlorpyrifos, an
organophosphate insecticide, was detected by the Oregon Department of Environmental
Quality in the Hood River and tributaries during March 1999 at levels exceeding state
water quality standards in the range of 0.011-0.482 μg/L....
