Polycyclic aromatic hydrocarbons (PAHs) are environmental contaminants produced mainly from the incomplete combustion and pyrolysis of organic matter. PAHs are among the major contaminants at over 800 Superfund sites, nationwide. Thermal remediation is used as a method to remediate soils contaminated with PAHs through the use of heat to mobilize...
Lycopodium alkaloids have shown widespread and noteworthy biological activity, consisting of over 250 known natural products. Moreover, their structural complexity and diversity have attracted considerable attention from numerous laboratories including our own. Recently, we have developed a unified approach that would provides access to numerous, previously unprepared C₁₀-functionalized lycopodium alkaloids....
Studies toward the total syntheses of highly potent cytotoxic alkaloids
including the bromopyrrole alkaloids and indole alkaloids were conducted and are
described. Studies carried out in the course of this dissertation consist of five total syntheses of natural products that include bromopyrrole alkaloids nagelamide A, D and agelastatin D as...
Normal adult rats absorbed and metabolized C¹⁴-labeled acetate
rapidly. The greatest percentage of the administered radioactivity
was recovered in the expired CO₂, however small amounts of radioactivity
were also found in the urine and feces. There were two rates
of C¹⁴O₂ elimination in normal adult rats. The small amount of...
More than 30 members of the diverse amphidinolide family of biologically active macrolides have been isolated over last three decades. From this family, amphidinolides C and F stand among the most complex and densely functionalized affiliates. Recently, we have accomplished the first total synthesis of amphidinolide F. The all-carbon framework...
Contaminant transport in ground water is an important environmental process that
affects a host of natural systems. Transport of contaminants is affected by many
processes, including aqueous complexation, adsorption, and redox reactions. One of the
most important components of an aquifer that controls transport is iron-oxide. In this
study, the...