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Filtering by: Subject DNA -- Synthesis Remove constraint Subject: DNA -- Synthesis Degree Field Genetics Remove constraint Degree Field: Genetics

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  • Mutagenic mechanisms associated with perturbations of DNA precursor biosynthesis in phage T4

    Creator:
    Ji, Jiuping
    Abstract:
    A crucial factor in determining the accuracy of DNA replication is maintenance of a balanced supply of deoxyribonucleoside triphosphates (dNTPs) at replication forks. Perturbation of dNTP biosynthesis can induce dNTP pool imbalance with deleterious genetic consequences, including increased mutagenesis, recombination, chromosomal abnormalities and cell death. Using the T4 bacteriophage system,...
    Resource Type:
    Dissertation
    Full Text:
    Mutagenic mechanisms associated with perturbations of DNA