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Filtering by: Subject Antifungal agents -- Synthesis Degree Field Pharmacy

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

Creator:

Grochowski, Laura L.

Abstract:

Molecular genetic and enzymological techniques have been employed to study secondary metabolite biosynthesis. These investigations have focused on two projects: the cloning and heterologous expression of biosynthetic gene clusters from unculturable marine organisms and the characterization of individual enzymes involved in the biosynthesis of the antifungal agent blasticidin S. The...

Resource Type:

Dissertation

Full Text:

involved in the biosynthesis of the antifungal agent blasticidin S. The marine environment is proving to
Studies toward the synthesis of coibamide A and analogues

Creator:

Li, Dong

Abstract:

Coibamide A is a highly methylated cyclic depsipeptide isolated from Panamanian marine filamentous cyanobacteria as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. This structurally unique agent exhibits potent cancer cell toxicity with an unprecedented selectivity profile in the National Cancer Institute (NCI) 60 cell line...

Resource Type:

Dissertation

Full Text:

) program based in Panama. This structurally unique agent exhibits potent cancer cell toxicity with an