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Filtering by: Subject Accelerator mass spectrometry Degree Field Toxicology

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Creator:

Madeen, Erin

Abstract:

The objective of this work is to add to the body of translational data between high dose animal model research and the environmentally relevant human metabolism of the persistent pollutant dibenzo[def,p]chrysene (DBC). We furthered the knowledge of gene/exposure interactions by determining the carcinogenesis risk based on Cyp1b1 genotype following in...

Resource Type:

Dissertation

Full Text:

across genotypes. In addition, sensitive accelerator mass spectrometry (AMS) was
Alkylation of peptides and proteins by S-(2-chloroethyl)glutathione and characterization of adducts by mass spectrometry

Creator:

Erve, John C. L.

Abstract:

Glutathione, a ubiquitous intracellular tripeptide, protects cells by reacting with electrophiles and radicals that can damage cellular macromolecules. However, glutathione conjugation is now recognized as one mechanism by which drugs and xenobiotics can also be converted to reactive intermediates having toxic consequences to cells. The halogenated alkane 1,2-dichloroethane forms S-(2-chloroethyl)...

Resource Type:

Dissertation

Full Text:

and Proteins by S-(2-chloroethyl) glutathione and Characterization of Adducts by Mass Spectrometry