Renibacterium salmoninarum is the causative agent of bacterial kidney disease in both
wild and farmed salmonid species worldwide. The genome of this pathogen has
significant synteny to the ubiquitous, soil-dwelling Arthrobacter spp. though it is 1.9 Mb
smaller, suggesting that reductive evolution has occurred. Recently, our group finished
sequencing and...
Background: Lateral gene transfer (LGT) among C. trachomatis strains is common, both in isolates generated in the laboratory and those examined directly from patients. This is a challenging concept because there are very few examples of recent acquisition of foreign DNA by Chlamydia spp. There is no understanding of the...
Xenobiotic exposures may induce alternative splicing in the pre-mRNA of nuclear hormone receptor (NHR) genes, yielding unpredictable patterns of gene expression that may promote adverse drug events and promote environmental disease. Informed by observations in the androgen receptor (AR; class I NHR), whereby alternatively-spliced AR transcripts induce ligand-independent hormone signaling...
Circadian clocks are internal mechanisms regulating many physiological processes.
Research suggests that the circadian clock may regulate repair of cellular damage caused
by reactive oxygen species (ROS), but molecular pathways from the clock to ROS repair
are not known. The gene cncC, known in mammals as Nrf2, and its repressor...
Embryonic development, where organs and major structures begin to develop, requires precise coordination of numerous gene regulatory pathways. Fendrr is an long non-coding RNA (lncRNA) that plays a role in regulating gene expression in mesodermal tissues during early embryonic development in mouse. The lateral plate mesoderm (LPM) is an earlier...
The S-domain subfamily of receptor-like kinases (SD-RLKs) in plants is poorly characterized and the majority of genes have unknown functions. The goal of this study was to study the expansion of rice (Oryza sativa) SD-RLK subfamily, and characterize gene and protein structure and expression of its members using publicly available...
In order to reduce the cost of lignocellulosic ethanol production, a model was previously developed to predict the amount of fermentable sugar released based on parameters concerning both biomass and enzymes. To validate this model, enzymatic hydrolysis must be carried out using individual purified cellulase enzymes. Endo-1,4-β-D-glucanase I (EG I),...
Natural products from plants, bacteria, and fungi play an important role in society. Over the last 35 years, natural products and their derivatives have inspired over 60% of all FDA approved small-molecule drugs, and are among the top prescribed therapeutics.1-2 Fleming’s discovery of the fungal antibiotic penicillin started the “Golden...