Index Catalog // ScholarsArchive@OSU

Acute bioactivation and hepatotoxicity of ketoconazole in rat and the determinant presence of flavin-containing monooxygenase (FMO) isoforms in human duodenum, jejunum, ileum, and colon microsomes and Caco-2 cell line

Creator:: Buckholz, Cheryl J.
Abstract:: Two specific goals were addressed for this dissertation. First to investigate and identify the mechanistic profile of ketoconazole (KT)-induced hepatotoxicity by utilizing in vivo and in vitro approaches determining the mechanism of action for the hepatotoxicity incurred. To date, there has not been a mechanistic determination of the hepatotoxicity associated...
Resource Type:: Dissertation
Full Text:: Hepatotoxicity of Ketoconazole in Rat and the Determinant Presence of Flavin-containing Monooxygenase (FMO

Product formulation of phenylbutazone, theophylline, tolbutamide and pharmacokinetics-toxicities of theophylline injections in pigs

Creator:: Suvanakoot, Uthai
Abstract:: A two-part study was conducted with three poorly water soluble drugs (phenylbutazone, tolbutamide, theophylline) to develop two new drug delivery systems based on physical-chemical approaches. In the first part, tolbutamide and phenylbutazone were made into solid dispersions with various excipients using a lyophilization technique. In vitro dissolution studies of these...
Resource Type:: Dissertation
Full Text:: physiological availability from solid dosage forms are largely dependent upon having the drug in the dissolved

Hemoglobin adducts of the organophosphate insecticide azinphos-methyl

Creator:: Bailey, Bonnie J.
Abstract:: Reported here is an investigation to determine if azinphos-methyl (AZM), an organophosphate insecticide, adducts to hemoglobin, and if so, whether the hemoglobin adduct could be used as a quantitative marker of occupational AZM exposure. We hypothesized that AZM, or a metabolite of AZM, binds to hemoglobin in erythrocytes forming an...
Resource Type:: Dissertation
Full Text:: ) (Gallo and Lawryk, 1991). Both cytochrome P450 and flavin-containing monooxygenase may be 7 involved

Indole-3-carbinol and 3,3'-diindolylmethane : relative potency as modulators of drug metabolism and carcinogenesis

Creator:: Katchamart, Sirinmas
Abstract:: Indole-3-carbinol (I3C), the most abundant metabolite of glucobrassicins, is found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and cauliflower. I3C has been shown to have anticarcinogenic activity against many chemical carcinogens in multiple target organs in animal models. However, the anticarcinogenic activity of I3C is considered indirect since...
Resource Type:: Dissertation
Full Text:: (cytochrome P4501A) and inhibits FMO1 (flavin-containing monooxygenase form 1) expression in rat liver and

Terminal oxidation pathways in Acetobacter suboxydans

Creator:: Kitos, Paul Alan
Resource Type:: Dissertation
Full Text:: . . . . . . . . . . . . . , . 64 1. pH Effect on aueose Oxidation . . . 6 2. Nuoleotide 3pecificity of G-o-P Dehydrogenase and

Certain physiological and pharmacological effects of radiation on rabbits

Creator:: Wagelie, Edwin Gan
Abstract:: Data were taken, following irradiation exposure to 100r and 300r cumulative dose, on 89 rabbits of three breeds that vary greatly in body size. Hematological, intestinal motility, and ear vascularity examinations were performed. Least square estimates have been obtained and an analysis of variance has been conducted in order estimate...
Resource Type:: Dissertation
Full Text:: Certain Physiological and Pharmacological Effects of

Use of radiation resistant organism as a protectant from lethal effects of irradiation in mice

Creator:: Kilbourn, Joan Priscilla Payne
Resource Type:: Dissertation
Full Text:: irradiation protected some of them from a lethal dose of irradiation. The effect of extracts from the

A metabolic function of selenium, assessed with rat liver homogenates

Creator:: Bull, Richard Charles
Abstract:: In three separate trials rats were fed either a basal diet deficient in selenium and vitamin E or the same diet supplemented with one or both of these factors. In addition to these treatments in two of the trials, ethoxyquin was included to provide adequate lipid antioxidant protection and to...
Resource Type:: Dissertation
Full Text:: beneficial effect upon reproduction in the rat. Somewhat later Poley et al. (1941), also conducting a

Effects of radiation on selection progress in mice

Creator:: Womack, James Ernest
Abstract:: The effects of x-irradiation on quantitative genetic traits was investigated by comparing the response of irradiated mice to selection for litter size and 28-day weight with the response to selection for the same two traits in non-irradiated lines. Irradiated lines were maintained at three levels of x-irradiation, 25 r, 50...
Resource Type:: Dissertation
Full Text:: interaction of genetic and physiological factors was assumed to be responsible for the reduced fertility

Manganese absorption by barley roots

Creator:: Maas, E. V. (Eugene Vernon), 1936-
Abstract:: An investigation of Mn uptake by five-day-old excised barley roots revealed that a metabolically-mediated process was involved. In short-term experiments, the rate of Mn absorption was comparable to that of the macronutrient cations. Like other metabolically absorbed cations, the Mn absorption rate was a direct function of the ambient concentration...
Resource Type:: Dissertation
Full Text:: studied, Li alone had a pronounced stimulatory effect while Na, K and Rb markedly reduced the absorption

ScholarsArchive@OSU

Acute bioactivation and hepatotoxicity of ketoconazole in rat and the determinant presence of flavin-containing monooxygenase (FMO) isoforms in human duodenum, jejunum, ileum, and colon microsomes and Caco-2 cell line

Product formulation of phenylbutazone, theophylline, tolbutamide and pharmacokinetics-toxicities of theophylline injections in pigs

Hemoglobin adducts of the organophosphate insecticide azinphos-methyl

Indole-3-carbinol and 3,3'-diindolylmethane : relative potency as modulators of drug metabolism and carcinogenesis

Terminal oxidation pathways in Acetobacter suboxydans

Certain physiological and pharmacological effects of radiation on rabbits

Use of radiation resistant organism as a protectant from lethal effects of irradiation in mice

A metabolic function of selenium, assessed with rat liver homogenates

Effects of radiation on selection progress in mice

Manganese absorption by barley roots

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