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Filtering by: Committee Member Kioussi, Chrissa Remove constraint Committee Member: Kioussi, Chrissa Degree Level Master's Remove constraint Degree Level: Master's

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  • Functional analysis of novel β-catenin mutants

    Creator:
    Al-Fageeh, Mohamed B.
    Abstract:
    β-catenin is a multi functional protein that is involved in cell-cell adhesion and cell signaling. In non-stimulated cells, β-catenin is tightly down-regulated by GSK-3β-dependent phosphorylation at Ser and Thr residues, followed by rapid ubiquitination and proteasomal degradation. It is well established that mutations within the regulatory GSK-3β region lead to...
    Resource Type:
    Masters Thesis
    Full Text:
    would like to thank Dr. Andrew Buermeyer, Dr.Chrissa Kioussi and Dr. Jeffrey Widrick for being on my