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Filtering by: Creator Taratula, Oleh Remove constraint Creator: Taratula, Oleh Degree Name Doctor of Philosophy (Ph.D.) Remove constraint Degree Name: Doctor of Philosophy (Ph.D.)

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  • A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

    Creator:
    Schumann, Canan B.
    Abstract:
    Ovarian cancer, “the silent killer,” is one of the deadliest gynecological diseases due to delayed diagnosis, leading to a heavily disseminated and aggressive metastatic cancer. Therapeutic options are limited at stages III-IV of ovarian cancer, in which debulking surgery and cytotoxic chemotherapy remain the mainstays of intervention. However, these therapeutic...
    Resource Type:
    Dissertation
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    for the Treatment of Metastatic Ovarian Cancer. Abstract approved: Oleh Taratula

  • Systemically Delivered Magnetic Hyperthermia for Cancer Treatment

    Creator:
    Albarqi, Hassan Ahmad M.
    Abstract:
    Despite advances in treatment, cancer remains among the leading causes of death in the world. Progress in the treatment of metastatic cancers was seen with chemotherapy and radiotherapy, however, the major drawbacks of conventional cancer therapies are limited efficacy and severe side effects. Magnetic fluid hyperthermia (MFH) is a new...
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    Dissertation
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    : ______________________________________________________ Oleh Taratula Despite advances in treatment, cancer remains among the leading causes

  • Advancing Nanotechnology for Photoacoustic Imaging

    Creator:
    St Lorenz, Anna
    Abstract:
    Curbing overall disease burden with faster intervention requires early stage and accurate diagnostics. Ultrasound (US) provides a safe, nonionizing, inexpensive, and noninvasive imaging modality that has become commonplace in diagnostics. Paired with the relatively new technology of photoacoustic imaging (PAI), optical level resolution becomes feasible with the deeper signal penetration...
    Resource Type:
    Dissertation
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    : ____________________________________________________ Oleh Taratula Curbing overall disease burden with faster intervention requires early

  • Development of Novel Therapeutic Approach for Ewing’s Sarcoma Treatment

    Creator:
    Sabei, Fahad Yahya
    Abstract:
    Ewing sarcoma (EwS) is the second most highly malignant tumor that arises mainly from bone and surrounding soft tissue of adolescent and young adult patients. Despite the advances in Ewing sarcoma treatment that today include a combination of five chemotherapeutic agents, surgery, and/or radiotherapy, these therapies have demonstrated limited improvement...
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    Dissertation
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    : ______________________________________________________ Oleh Taratula Ewing sarcoma (EwS) is the second most highly malignant tumor that arises mainly

  • Non-viral Vectors for Ocular Gene Delivery

    Creator:
    Herrera-Barerra, Marco, F.
    Abstract:
    Nucleic acid therapeutics has cemented itself as one of the most efficacious and robust avenues for treatment of a wide range of diseases from vaccine development to treatment of liver, retina, cancer applications. Non-viral mediated gene delivery using lipid-based nanoparticle (LNP) carriers has proven its compatibility with addressing unexpected, fast...
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    Dissertation
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    . Oleh Taratula and Dr. Conroy Sun provided input during for manuscript finalization. Dr. Gaurav

  • Application of Bootstrap Methods in Bioequivalence Studies for Oral Generic Prodrug Products

    Creator:
    Li, Wenjing
    Abstract:
    The methodology to perform bioequivalence studies for prodrug products has not been finalized by FDA leaving the investigators to speculate over the proper approach. This study innovatively utilized the bootstrap methods for testing in vivo bioequivalence on both parent drug and metabolite of four prodrug products: Clopidogrel, Prednisone, Allopurinol, and...
    Resource Type:
    Dissertation
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    . committee: Adam Alani, Ph.D.; Harold Bae, Ph.D.; Oleh Taratula, Ph.D.; and Lan Xue, Ph.D.. Without their

  • Transdermal Delivery of Atenolol to Cats

    Creator:
    Mohamed, Sumeia M.
    Abstract:
    This thesis describes in-vitro and in-vivo evaluation of a transdermal atenolol formulation developed at Oregon State University, College of Pharmacy. The formulation was prepared from carbomer as a gel base with propylene glycol, glycerol, ethanol, polysorbate 80 and dimethyl-isosorbide (DMI) as mixture of penetration enhancing agents. The effect of the...
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    Dissertation
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    thesis committee: Dr Oleh Taratula, Dr. Gaurav Sahay and Dr. Sun Conroy for their encouragement

  • Development of thermosensitive injectable hydrogel and transdermal controlled release formulations for Tacrolimus

    Creator:
    Nguyen, Duc X.
    Abstract:
    TAC is the most commonly used medication in post transplantation maintenance immunosuppression therapy. TAC lipophilicity and its erratic oral absorption especially in the presence of food intake result in great intra- and interpatient pharmacokinetic variations. Complicated dosing and frequent required therapeutic monitoring is thought to be the main cause of...
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    Dissertation
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    many other works. I would like to thank my committee members Dr. Mark Christensen, Dr. Oleh Taratula

  • Pharmacokinetics of Flunixin in Elephants, Cefovecin in African Lions, and Gamithromycin in Alpacas

    Creator:
    Alshahrani, Sultan M.
    Abstract:
    Foot pathology is a real problem in captive elephants. Osteoarthritis is the major concern among musculoskeletal disorders and foot health problems for elephants in North America zoos with one-­‐half of Elephants in captivity showing foot health care problems in zoos. A higher ratio of captive Asian elephants (Elephas maximus) is...
    Resource Type:
    Dissertation
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      committee  members   Dr.   Adam  Alani,   Dr.   Oleh   Taratula,   and   Dr.   Conroy

  • Development of Micellar and Nanoparticle Structures based on Polyester Diblock Copolymer Platform for the Treatment of Metastatic Tumors

    Creator:
    Doddapaneni, Bhuvana S.
    Abstract:
    Poor aqueous solubility of a large number of newly discovered chemical entities is posing a significant challenge for the formulation industry and is delaying their drug development. The number of formulation techniques available to solubilize these poorly soluble molecules is very limited. In addition to that, traditional formulation methods involve...
    Resource Type:
    Dissertation
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    my committee members Dr Oleh Taratula, Dr Mark Christensen, Dr Arup Indra and Dr Julie Greenwood