Index Catalog // ScholarsArchive@OSU

Sex and Survival: Reproduction and Anti-Microbial Defense in the Red-Sided Garter Snake (Thamnophis sirtalis parietalis)

Creator:: Blakemore, Leslie A.
Abstract:: The red-sided garter snakes (Thamnophis sirtalis parietalis) of Manitoba, Canada, have been extensively studied for decades with little investigation into their immune system. These animals live very close to the arctic circle and spend over half of the year underground brumating. The annual cycle of the red-sided garter snakes make...
Resource Type:: Masters Thesis
Full Text:: project without him. Doug Warrick and Mark Leid provided thoughtful insight and support, thank you both

Unraveling tissue regeneration using chemical genetics

Creator:: Mathew, Lijoy K.
Abstract:: The emerging field of regenerative medicine is mainly approached by two different aspects. First is the use of stem cell based models to generate a suite of differentiated cells for therapeutic applications and the alternative approach is to utilize the non-mammalian models that have the inherent capacity to regenerate their...
Resource Type:: Dissertation
Full Text:: to thank all my committee members, namely, Dr. David Williams, Dr. Nancy Kerkvliet, Dr. Mark Leid

Alkylation kinetics of the human retinoid X receptor α using cysteine as a local probe

Creator:: Vanegas, Juan Manuel
Abstract:: The unfolding of human retinoid X receptor α in the presence of the denaturant guanidine HCl was studied using stopped-flow absorbance spectroscopy. The protein's four native cysteine residues were mutated to obtain four single-cysteine mutants, each with the other three cysteine residues mutated to alanine. The thiols of these hRXRα...
Resource Type:: Masters Thesis
Full Text:: Local Probe Juan M. Vanegas1, Michael I. Schimerlik1, David Broderick1, Mark Leid2, Max L. Deinzer3

A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

Creator:: Schumann, Canan B.
Abstract:: Ovarian cancer, “the silent killer,” is one of the deadliest gynecological diseases due to delayed diagnosis, leading to a heavily disseminated and aggressive metastatic cancer. Therapeutic options are limited at stages III-IV of ovarian cancer, in which debulking surgery and cytotoxic chemotherapy remain the mainstays of intervention. However, these therapeutic...
Resource Type:: Dissertation
Full Text:: ), Dr. Christenson (his stories will forever live on in my memories), Dr. Mark Zabriskie, Dr. Mark

Transcription factor CTIP2 regulates hair follicle development, hair cycling and wound healing

Creator:: Bhattacharya, Shreya
Abstract:: The integumentary system is the largest organ system of the body that comprises of skin and its appendages such as hair follicles, sebaceous and sweat glands. Skin is divided into three distinct structural layers: the epidermis, dermis and hypodermis. The epidermis originates from the ectoderm and is composed of four...
Resource Type:: Dissertation
Full Text:: embryonic skin. Dr. Mark Leid has done the critical analysis of the manuscript. Chapter 4: Shreya

Cellular Recognition, Division, and Proliferation in the Cnidarian-Dinoflagellate Symbiosis

Creator:: Tivey, Trevor R.
Abstract:: Cnidarians and their symbiotic dinoflagellates form a productive mutualism that shapes marine environments. In this symbiosis, dinoflagellate species from the family Symbiodiniacea reside within cnidarian host gastrodermal cells and provide the host with photosynthetically fixed carbon in exchange for host metabolites. This nutritional exchange allows both partners to thrive in...
Resource Type:: Dissertation
Full Text:: members of my committee, Barb Taylor, Tom Sharpton, Eli Meyer, Mark Leid, and Jim Strother for their

Bcl11b is at the Nexus of Wnt and MAP Kinase Signaling Pathways in Two Stages of Thymocyte Development

Creator:: Selman, Wisam H.
Abstract:: Leukemogenesis, uncontrolled proliferation of dysfunctional, transformed immature lymphocytes, appears, especially in children, to be associated with abrogation of normal lymphopoiesis, and thymopoiesis in the case of T cell leukemias. Sequence specific transcription factors (SSTFs) are nuclear control switches that respond to cellular signals to alter cell state and cell fate...
Resource Type:: Dissertation
Full Text:: 2.6C & D, and performed transfection of HEK293T cells needed for results in Figure 2.6B. Mark Leid

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Creator:: Garcia, Gloria R.
Abstract:: The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is a member of the basic helix-loop-helix PER-ARNT-SIM (bHLH/PAS) protein family of cellular sensors. The AHR is conserved across multiple animal phyla and is required for proper vertebrate development. A structurally diverse group of chemicals, including polycyclic aromatic...
Resource Type:: Dissertation

Role of Transcriptional Factor COUP-TF-interacting Proteins in Skin Permeability Barrier Development, and in Skin Carcinogenesis, and Role of Lipids in Atopic Dermatitis

Creator:: Li, Shan
Abstract:: Mammalian skin is the largest organ of the body and serves as a barrier to protect the body against chemical, mechanical and pathogenic insults as well as water loss. The epidermis is formed from the primitive ectoderm into a multilayered stratified epithelium, consisting of basal, spinous, granular and outermost cornified...
Resource Type:: Dissertation
Full Text:: All the past and present members of the Indra Lab All my dissertation committees (Dr. Mark Leid

Roles for retinoid-X-receptors in solar UV-induced melanocyte homeostasis and melanomagenesis

Creator:: Coleman, Daniel J.
Abstract:: Melanoma is the deadliest form of skin cancer, arising from malignant transformation of pigment-producing melanocytes. The primary risk factor for melanoma and other skin cancers is DNA damage resulting from unprotected solar ultraviolet radiation (UVR). If incorrectly repaired, this damage can result in incorporation of mutations that cause aberrant cell...
Resource Type:: Dissertation

ScholarsArchive@OSU

Sex and Survival: Reproduction and Anti-Microbial Defense in the Red-Sided Garter Snake (Thamnophis sirtalis parietalis)

Unraveling tissue regeneration using chemical genetics

Alkylation kinetics of the human retinoid X receptor α using cysteine as a local probe

A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

Transcription factor CTIP2 regulates hair follicle development, hair cycling and wound healing

Cellular Recognition, Division, and Proliferation in the Cnidarian-Dinoflagellate Symbiosis

Bcl11b is at the Nexus of Wnt and MAP Kinase Signaling Pathways in Two Stages of Thymocyte Development

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Role of Transcriptional Factor COUP-TF-interacting Proteins in Skin Permeability Barrier Development, and in Skin Carcinogenesis, and Role of Lipids in Atopic Dermatitis

Roles for retinoid-X-receptors in solar UV-induced melanocyte homeostasis and melanomagenesis

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