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  • Acute bioactivation and hepatotoxicity of ketoconazole in rat and the determinant presence of flavin-containing monooxygenase (FMO) isoforms in human duodenum, jejunum, ileum, and colon microsomes and Caco-2 cell line

    Creator:
    Buckholz, Cheryl J.
    Abstract:
    Two specific goals were addressed for this dissertation. First to investigate and identify the mechanistic profile of ketoconazole (KT)-induced hepatotoxicity by utilizing in vivo and in vitro approaches determining the mechanism of action for the hepatotoxicity incurred. To date, there has not been a mechanistic determination of the hepatotoxicity associated...
    Resource Type:
    Dissertation
    Full Text:
    Hepatotoxicity of Ketoconazole in Rat and the Determinant Presence of Flavin-containing Monooxygenase (FMO

  • Composition of flavonoid phenolic polymers isolated from red wine during maceration and significance of flavan-3-ols in foods pertaining to biological activity

    Creator:
    Aron, Patricia M.
    Abstract:
    Representing the most common flavonoid consumed in the American diet, the flavanols and their polymeric condensation products, the proanthocyanidins, are regarded as functional ingredients in various beverages, whole and processed foods, herbal remedies and supplements. Their presence in food affects food quality parameters including astringency, bitterness, sourness, sweetness, salivary viscosity,...
    Resource Type:
    Masters Thesis
    Full Text:
    Effect on food quality............................................................................6

  • Investigations of gluten proteins from functional and historical perspective

    Creator:
    Zhang, Ying
    Abstract:
    Wheat (Triticum aestivum) is one of the world’s major staple food crops, with flour produced from starchy endosperm being used for breads, cakes, noodles and various other wheat-based foods. The unique bread making properties of wheat are primarily attributed to its gluten-forming storage proteins: gliadins and glutenins. This study investigated...
    Resource Type:
    Masters Thesis
    Full Text:
    )..………………………………………………64 3.2 Two-way ANOVA results of control effect…………………………………64 3.3 Onset temperatures under

  • Purification and characterization of recombinant calpain-5

    Creator:
    Wang, Mei-Chuan
    Abstract:
    Recombinant human calpain-5 was expressed in insect cells using a baculovirus system. The expressed calpain-5 was purified by both traditional chromatography and by affinity-column chromatography. Both methods yielded active protease. Calpain-5 displayed very limited hydrophobicity. This indicated that calpain-5 is not a membrane binding protein. Calpain-5 had pI of 8.3....
    Resource Type:
    Dissertation
    Full Text:
    cysteine proteases. Although the exact physiological roles of calpains remain to be elucidated, calpains

  • Estimation of the energy cost of walking 10,000 steps

    Creator:
    Birdsley, Kari L.
    Abstract:
    There is a strong campaign underway to promote increased physical activity among the U.S. population. The U.S. Surgeon General and the U.S. Dietary Guidelines have presented physical activity recommendations in terms of the amount of time accumulated in physical activity and/or in terms of energy expenditure over the course of...
    Resource Type:
    Masters Thesis
    Full Text:
    activity has a positive effect on one's physical well being. The American College of Sports Medicine

  • Exercise, nutrition, and homocysteine

    Creator:
    Joubert, Lanae Marie
    Abstract:
    Exercise increases B-vitamin (B6, B12, folate) dependent metabolic reactions, especially those related to energy production and the rebuilding and repairing of muscle tissue. These same B-vitamins are also important in maintaining low blood levels of homocysteine (Hcy), a cardiovascular disease (CVD) risk factor. Hcy levels rise when the metabolism of...
    Resource Type:
    Dissertation
    Full Text:
    exercise intensity is vigorous. Research examining the effect of exercise on Hcy is limited with no

  • Vitamin E and K interactions : investigating mechanisms of reduced vitamin K status in response to excess vitamin E

    Creator:
    Farley, Sherry Mae
    Abstract:
    The primary goal of my studies was to elucidate the mechanisms for the well-recognized interaction between two nutrients, vitamins E and K. The outcomes from my studies assess mechanisms for adverse effects of vitamin E and provide novel information on mechanisms for vitamin K homeostasis. These findings will provide information...
    Resource Type:
    Dissertation
    Full Text:
    and d4-PK decreased in -T-injected rats demonstrating that vitamin E’s untoward effect on vitamin K

  • Impact of weak and strong acids on the destruction of lactic acid bacteria during high pressure processing

    Creator:
    Sarangapani, Rama Krishna
    Abstract:
    High hydrostatic pressure (HHP) affects the pH of weak acids due to an increased degree of acid dissociation while under pressure. The temporary pH reduction by high pressure in such a case may influence the barotolerance of microorganisms. The objective of this study was to determine the impact of weak...
    Resource Type:
    Masters Thesis
    Full Text:
    bacteria across a range of pH under high hydrostatic pressure conditions. The effect of two acid groups

  • The role of leptin in normal and pathological bone resorption

    Creator:
    Philbrick, Kenneth Alan
    Abstract:
    Particles generated from wear of prosthesis joint bearing surfaces induce inflammation and promote pathological periprosthetic osteoclast-mediated bone resorption (osteolysis). Obesity increases the risk of prosthesis failure. However, despite being morbidly obese, leptin-deficient ob/ob mice are resistant to osteolysis. These findings suggest that leptin exerts effects that act to increase particle-induced...
    Resource Type:
    Dissertation
    Full Text:
    .......................................................................................................................... 14 Study 2.2: Effect of housing temperature on particle-induced osteolysis in WT Study 2.3

  • Fibrinogen adsorption at heparinized silica interfaces : history dependence and protein concentration effects

    Creator:
    Joshi, Omkar
    Abstract:
    Adipic dihydrazide-modified heparin was prepared and subsequently immobilized on surface-activated silica wafers. X-ray photoelectron spectroscopy (XPS) was used to quantify the elemental composition of the silica surface at each stage of activation and results showed that successful immobilization had taken place. Contact angle measurements were made to verify the high...
    Resource Type:
    Masters Thesis
    Full Text:
    possible alternative is heparin immobilization on the biomaterial, so that the anticoagulant effect will