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  • Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

    Creator:
    Otto, Shauna C.
    Abstract:
    Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...
    Resource Type:
    Dissertation
    Full Text:
    roadblocks. I also thank my graduate committee, Dr. Elisar Barbar, Dr. Patrick Reardon, Dr. Joe Baio, and Dr

  • Beyond the paired-catchment approach : isotope tracing to illuminate stocks, flows, transit time, and scaling

    Creator:
    Hale, V. Cody
    Abstract:
    This dissertation integrates a process-based hydrological investigation with an ongoing paired-catchment study to better understand how forest harvest impacts catchment function at multiple scales. We do this by addressing fundamental questions related to the stocks, flows and transit times of water. Isotope tracers are used within a top-down catchment intercomparison...
    Resource Type:
    Dissertation
    Full Text:
    for Tina Garland, and my wife and “Isotope Princess”, Caroline Patrick, who put in an enormous