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  • Nongenomic Actions of Steroid Hormones in the Ovine Endometrium

    Creator:
    Ireton, Kyle E.
    Abstract:
    The steroid hormone estrogen plays a crucial role in regulating certain mammalian tissues, especially female reproductive systems. Estrogen effects physiological changes in the cell by altering transcription activity for certain target genes, as a consequence of interactions between estradiol-17β (E2) and its nuclear receptor (nER). This mechanism of cellular control...
    Resource Type:
    Honors College Thesis
    Full Text:
    ______________________________________________________________________________ Dr. Andrew Karplus, Committee Representative, Biochemistry and Biophysics

  • Mutagenesis and Crystallization of Ptr ToxB, a host-selective toxin of Pyrenophora tritici-repentis

    Creator:
    Miles-Rockenfield, Kara B.
    Abstract:
    Pyrenophora tritici-repentis (Ptr) is the fungal causal agent of the disease tan spot in wheat and causes necrosis and chlorosis in infected leaves. These symptoms are caused by host-selective toxins (HSTs), molecules that serve as the sole determinants of pathogenicity. Ptr has three known HSTs, the proteinaceous Ptr ToxA and...
    Resource Type:
    Honors College Thesis
    Full Text:
    , representing Botany and Plant Pathology Dr. P. Andrew Karplus, Committee Member, representing

  • Gene Structure and Expression of the Rice S-Domain Kinase (SD-RLK) Gene Subfamily

    Creator:
    Dikeman, Daemon
    Abstract:
    The S-domain subfamily of receptor-like kinases (SD-RLKs) in plants is poorly characterized and the majority of genes have unknown functions. The goal of this study was to study the expansion of rice (Oryza sativa) SD-RLK subfamily, and characterize gene and protein structure and expression of its members using publicly available...
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Andrew Karplus, Committee Member, representing Biochemistry and Biophysics

  • Crystal structures of DNA four-way junctions

    Creator:
    Eichman, Brandt F.
    Abstract:
    DNA four-way junctions (also known as Holliday junctions) are the primary structural intermediate during recombination, an important process responsible for biological evolution and maintenance of genomes. These junctions arise from the assembly of four nucleic acid strands to produce double-helical regions extending from a central point. Although much progress has...
    Resource Type:
    Dissertation
    Full Text:
    would also like to thank Dr. P. Andrew Karplus, as well as the rest of my committee for their helpful

  • The Impact of Causal Uncertainty on Dyadic Satisfaction

    Creator:
    Needham, Shana M.
    Abstract:
    One's ability to determine the cause and effect nature events is important for navigating within the social realm. However, the ability to determine these relationships is not always as clear. According to Weary and Edwards (1996) causal uncertainty (CU) is the result of an individual perceiving themselves as someone who...
    Resource Type:
    Masters Thesis
    Full Text:
    . Aurora Sherman, and Dr. Andrew Karplus for their invaluable guidance during the course of this project

  • Genomic-assisted determination of the natural nutrient requirements of the cosmopolitan marine bacterium 'Candidatus Pelagibacter ubique'

    Creator:
    Tripp, H. James
    Abstract:
    To identify factors limiting 'Candidatus Pelagibacter ubique' maximum cell density and growth rate in pure culture on seawater, the genome sequence of 'Cand. P. ubique' was analyzed, culturing experiments with organic and inorganic nutrient additions were made, and radiotracer uptake experiments were performed. The genome was sequenced, custom data mining...
    Resource Type:
    Dissertation

  • Characterization and Functionalization of Fabric for use in an Immunoassay

    Creator:
    White, Natalie
    Abstract:
    Paper-based microfluidic assays, like the common pregnancy test, allow for rapid screening at the point- of-care at low cost and with no instrumentation. Fabric has many similar properties to paper, but is more flexible and durable, making it a promising option for use in a variety of diagnostic and screening...
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Andrew Karplus, Committee Member, representing the Department of Biochemistry and Biophysics

  • The Role of Algal Cellular Physiology on the Onset and Maintenance of a Model Cnidarian-Algal Symbiosis

    Creator:
    Maruyama, Shumpei
    Abstract:
    Coral reefs form vast ecosystems in tropical oceans that are hotspots for biodiversity and are economically valuable. The ecological success of coral reefs is made possible by the symbiotic relationship between corals and dinoflagellate algae from the family Symbiodiniaceae. In this symbiosis, the algae are found within host gastrodermal cells...
    Resource Type:
    Dissertation
    Full Text:
    Anderson, and Andy Karplus. They have all provided me with great mentorship and have helped me improve

  • Pheromone Variation in Plethodontid Salamanders

    Creator:
    Chouinard, Adam J.
    Abstract:
    Plethodontid salamanders have served as an informative vertebrate system for studying the role of chemical signals in facilitating social and reproductive behaviors. Individuals produce complex mixtures of chemicals from multiple glandular regions. In total, these secretions convey a wide variety of information, and are important for numerous inter- and intraspecific...
    Resource Type:
    Dissertation
    Full Text:
    the support and guidance he has given me over the years. Likewise, Dr. Denver and Dr. Karplus have

  • Structural studies of the antioxidant defense enzymes; copper, zinc superoxide dismutase and alkyl hydroperoxide reductase flavoprotein

    Creator:
    Roberts, Blaine R.
    Abstract:
    Oxygen derived radicals are involved in many aspects of life from aging and cell signaling to disease states as diverse as heart disease, diabetes, neurodegeneration and inflammation. Therefore, understanding the function of antioxidant defense proteins and the effects of oxygen derived radicals on protein function is essential to elucidate the...
    Resource Type:
    Dissertation
    Full Text:
    like to extend my gratitude to Andy Karplus for all of his help in preparing manuscripts and