Index Catalog // ScholarsArchive@OSU

Part I: Synthetic studies toward the southern portion of Azaspiracid-1; Part II: Total synthesis of amphidinolide B₁ and the proposed structure of amphidinolide B₂

Creator:: Lu, Liang
Abstract:: The structural architecture present in marine toxin azaspiracid - 20 stereocenters, 9 rings, 3 separated spirocenters - has attracted considerable synthetic attention. Our efforts toward the synthesis of azaspiracid have led to the completion of both C₁-C₂₆ northern and C₂₇-C₄₀ southern halves. Herein, the synthesis of southern FGHI ring system...
Resource Type:: Dissertation
Full Text:: . The new strategy afforded the natural product in 39 linear steps. 1.22 6 8 steps Me O H OTBDPS

Biological characterization of coibamide A, a marine natural product from a Panamanian cyanobacterium

Creator:: Hau, Andrew M.
Abstract:: Coibamide A is a methyl-stabilized cyclic depsipeptide with a lariat side chain that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups program based in Panama. Previous testing of this potent and selective growth-inhibitory agent in the National Cancer Institute (NCI) in vitro 60 human...
Resource Type:: Dissertation
Full Text:: : Biological Characterization of Coibamide A, a Marine Natural Product from a Panamanian Cyanobacterium

Biologically active cyclic depsipeptides from marine cyanobacteria

Creator:: Medina, Rebecca A.
Abstract:: This thesis describes the chemical investigation of marine cyanobacteria collected in Madagascar and Panama with an emphasis on the isolation and structure elucidation of medicinally relevant secondary metabolites. A collection of the marine cyanobacterium Lyngbya majuscula from the Radames Islands, Madagascar yielded two new cyclic depsipeptides, radamamides A and B,...
Resource Type:: Dissertation
Full Text:: evaluation in the late 1980’s and became the first marine-derived natural product to enter clinical trials

Mandelalides as Potent Mitochondrial ATP Synthase Inhibitors : From Discovery of New Analogs to Function-Oriented Synthetic Studies

Creator:: Nazari, Mohamad
Abstract:: Our quest for pharmaceutically important marine natural products led to re-isolation of known mandelalides A-D and identification of new congeners E-L from re-collected South African Lissoclinum tunicate specimens. Mandelalides A, B, and L were characterized as selective cancer cell toxins, with an unusual activity profile influenced by their glycosylation /...
Resource Type:: Dissertation
Full Text:: Kerry L. McPhail Our quest for pharmaceutically important marine natural products led to re-isolation

Studies toward the synthesis of coibamide A and analogues

Creator:: Li, Dong
Abstract:: Coibamide A is a highly methylated cyclic depsipeptide isolated from Panamanian marine filamentous cyanobacteria as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. This structurally unique agent exhibits potent cancer cell toxicity with an unprecedented selectivity profile in the National Cancer Institute (NCI) 60 cell line...
Resource Type:: Dissertation
Full Text:: natural product coibamide A according to HPLC, 1H NMR and activity test. By Marfey’s analysis, we found

Investigation of unique marine environments for microbial natural products

Creator:: Thornburg, Christopher C.
Abstract:: Metagenomics has revealed that the marine microbial biosphere is immensely more diverse than originally considered, and is an almost untapped reservoir for the potential discovery of microbial natural products. Despite numerous advances in culturing, biosynthetic engineering and genomic-based screening efforts to uncover much of this diversity in relatively accessible environments,...
Resource Type:: Dissertation
Full Text:: ......................................................................Microbial Natural Products 2 ...........................................................Marine Bacterial

Studies towards the total syntheses of (+)-phomactins A, D and G

Creator:: Schwartz, Keith D.
Abstract:: Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal metabolites with unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 354 and 356, which contain all of the carbon atoms of 1, 6 and 9....
Resource Type:: Dissertation
Full Text:: synthesis of analogs in drug discovery. The pursuit of natural product synthesis is an important

Biologically active metabolites from marine microorganisms : methods to identify drug leads and chemical signals

Creator:: Vining, Oliver B.
Abstract:: Microbial natural products represent a massive repository of unique chemical scaffolds with corresponding diverse biological functions. However, in the past decade the development of natural products into new therapeutics has dwindled, in part due to the challenges posed by high rediscovery rates and low throughput associated with classical bioassay-guided fractionation...
Resource Type:: Dissertation
Full Text:: -2.19 Phylogenetic tree of known natural product-producing marine cyanobacteria in relation to strain

Structure elucidation of bioactive natural products from Madagascar marine algae and cyanobacteria

Creator:: Andrianasolo, Eric Hajaniriana
Abstract:: This thesis is an investigation of the natural products deriving from marine algae and cyanobacteria and has resulted in the discovery of eleven new secondary metabolites. The structure elucidations of these new molecules were performed using a variety of spectroscopic techniques. Four new macrolides were isolated and characterized from the...
Resource Type:: Dissertation
Full Text:: ELUCIDATION OF BIOACTIVE NATURAL PRODUCTS FROM MADAGASCAR MARINE ALGAE AND CYANOBACTERIA

Synthesis of marine natural products. part I, Cryptophycins-1, -3, -4, -24, and -29, part II, Polycavernoside A

Creator:: Robarge, Lonnie A.
Resource Type:: Dissertation
Full Text:: Synthesis of marine natural products. part I, Cryptophycins-1

ScholarsArchive@OSU

Part I: Synthetic studies toward the southern portion of Azaspiracid-1; Part II: Total synthesis of amphidinolide B₁ and the proposed structure of amphidinolide B₂

Biological characterization of coibamide A, a marine natural product from a Panamanian cyanobacterium

Biologically active cyclic depsipeptides from marine cyanobacteria

Mandelalides as Potent Mitochondrial ATP Synthase Inhibitors : From Discovery of New Analogs to Function-Oriented Synthetic Studies

Studies toward the synthesis of coibamide A and analogues

Investigation of unique marine environments for microbial natural products

Studies towards the total syntheses of (+)-phomactins A, D and G

Biologically active metabolites from marine microorganisms : methods to identify drug leads and chemical signals

Structure elucidation of bioactive natural products from Madagascar marine algae and cyanobacteria

Synthesis of marine natural products. part I, Cryptophycins-1, -3, -4, -24, and -29, part II, Polycavernoside A

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