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Filtering by: Creator Hermanson, Ola Resource Type Article

Pitx2 expression induces cell cycle exit and p21 expression in neural stem cells

Creator:

Heldring, Nina, Joseph, Bertrand, Hermanson, Ola, and Kioussi, Chrissa

Abstract:

Cortical development is a complex process that involves many events including proliferation, cell cycle exit, and differentiation that need to be appropriately synchronized.. Neural stem cells (NSCs) isolated from embryonic cortex are characterized by their ability of self-renewal under continued maintenance of multipotency. The G1 phase of the cell cycle...

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p21 expression in neural stem cells Nina Heldring1, Bertrand Joseph2, Ola Hermanson1, 4
Population-Specific Regulation of Chmp2b by Lbx1 during Onset of Synaptogenesis in Lateral Association Interneurons

Creator:

Xu, Jun, Nonogaki, Mariko, Madhira, Ravi, Ma, Hsiao-Yen, Hermanson, Ola, Kioussi, Chrissa, and Gross, Michael K.

Abstract:

Chmp2b is closely related to Vps2, a key component of the yeast protein complex that creates the intralumenal vesicles of multivesicular bodies. Dominant negative mutations in Chmp2b cause autophagosome accumulation and neurodegenerative disease. Loss of Chmp2b causes failure of dendritic spine maturation in cultured neurons. The homeobox gene Lbx1 plays...

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Madhira1, Hsiao-Yen Ma1, Ola Hermanson2, Chrissa Kioussi1, Michael K. Gross1* 1 Department of