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Filtering by: Publisher Landes Bioscience, Inc. Resource Type Article

Blood-based profiles of DNA methylation predict the underlying distribution of cell types: a validation analysis

Creator:

Koestler, Devin C., Christensen, Brock C., Karagas, Margaret R., Marsit, Carmen J., Langevin, Scott M., Kelsey, Karl T., Wiencke, John K., and Houseman, E. Andres

Abstract:

The potential influence of underlying differences in relative leukocyte distributions in studies involving blood-based profiling of DNA methylation is well recognized and has prompted development of a set of statistical methods for inferring changes in the distribution of white blood cells using DNA methylation signatures. However, the extent to which...

Resource Type:

Article
Lin28 Regulates BMP4 and Functions with Oct4 to Affect Ovarian Tumor Microenvironment

Creator:

Ma, Wei, Ma, Jing, Xu, Jie, Qiao, Chong, Branscum, Adam, Cardenas, Andres, Baron, Andre T., Schwartz, Peter, Maihle, Nita J., and Huang, Yingqun

Abstract:

Emerging evidence suggests that the tumor microenvironment plays a critical role in regulating cancer stem cells (CSCs) and tumor progression through both autocrine and paracrine signaling. Elevated production of bone morphogenetic proteins (BMPs) from human ovarian cancer cells and stroma has been shown to increase CSC proliferation and tumor growth....

Resource Type:

Article