Index Catalog // ScholarsArchive@OSU

Creator:: Krishnan, Natraj, Kretzchmar, Doris, Rakshit, Kuntol, Chow, Eileen, and Giebultowicz, Jadwiga M.
Abstract:: There is increasing evidence that aging is affected by biological (circadian) clocks – the internal mechanisms that coordinate daily changes in gene expression, physiological functions and behavior with external day/night cycles. Recent data suggest that disruption of the mammalian circadian clock results in accelerated aging and increased age‐related pathologies such...
Resource Type:: Article
Full Text:: period extends healthspan in aging Drosophila melanogaster Natraj Krishnan1, Doris Kretzschmar2

Creator:: Rakshit, Kuntol, Krishnan, Natraj, Guzik, Elzbieta M., Pyza, Elzbieta, and Giebultowicz, Jadwiga M.
Abstract:: Circadian clocks maintain temporal homeostasis by generating daily output rhythms in molecular, cellular, and physiological functions. Output rhythms, such as sleep/wake cycles and hormonal fluctuations, tend to deteriorate during aging in humans, rodents, and fruit flies. However, it is not clear whether this decay is caused by defects in the...
Resource Type:: Article
Full Text:: @science.oregonstate.edu. The current address of Natraj Krishnan is Department of Biochemistry, Molecular Biology

Creator:: Krishnan, Natraj, Rakshit, Kuntol, Chow, Eileen S., Wentzell, Jill S., Kretzschmar, Doris, and Giebultowicz, Jadwiga M.
Abstract:: Circadian clocks generate rhythms in molecular, cellular, physiological, and behavioral processes. Recent studies suggest that disruption of the clock mechanism accelerates organismal senescence and age-related pathologies in mammals. Impaired circadian rhythms are observed in many neurological diseases; however, it is not clear whether loss of rhythms is the cause or...
Resource Type:: Article
Full Text:: 1 Loss of circadian clock accelerates aging in neurodegeneration-prone mutants Natraj

ScholarsArchive@OSU