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  • The Generation of a Zebrafish Microbial Culture Collection to Facilitate Mechanistic Understanding of Host-Microbe Interactions

    Creator:
    VanderHoek, Zoe K.
    Abstract:
    A rapidly expanding body of evidence suggests that relationships exist between the microbiome and vertebrate health and disease. The zebrafish is a frequently utilized model organism to support this claim. Specifically, its gut microbiome is an advantageous resource for the study of microbiome health and diversity. While it is an...
    Resource Type:
    Honors College Thesis
    Full Text:
    Thomas Sharpton A rapidly expanding body of evidence suggests that relationships exist between

  • Using the Microbial Tree of Life to Describe Mammalian Health and Disease

    Creator:
    Arnold, Holly Kristin
    Abstract:
    The past decade of research has potentiated a revolution in our understanding of mammalian health and evolution by revealing that the gut microbiome plays a central role in mammalian physiology. Our ability to unlock this potential hinges upon the identification of specific groups of gut microbes that elicit effects on...
    Resource Type:
    Dissertation
    Full Text:
    Thomas J. Sharpton The past decade of research has potentiated a revolution in our understanding

  • The Gut Microbiome Drives Benzo[a]pyrene's Impact on Zebrafish Behavioral Development

    Creator:
    Sieler, Michael J.
    Abstract:
    Benzo[a]pyrene (B[a]P) is a common environmental pollutant produced from the incomplete combustion of organic matter, such as fossil fuel emissions. In vertebrates, B[a]P exposure is associated with hyperactivity, though the underlying mechanisms driving this effect are undescribed. Mounting evidence indicates that the gut microbiome, which is the diverse community of...
    Resource Type:
    Undergraduate Thesis
    Full Text:
    APPROVED: _____________________________________________________ _______________ Thomas J

  • Characterizing the Accuracy of Phylogenetic Analyses that Leverage 16S rRNA Sequencing Data

    Creator:
    Humphreys, Ian R.
    Abstract:
    Investigations of 16S rRNA gene sequences hallmark modern microbiology. These sequences provide culture-independent insight into the abundance and distribution of microbiota and serve as a principle resource through which microbial community diversity is measured. Consequently, researchers rely on 16S gene sequences to test hypotheses rooted in ecology, evolution, and disease....
    Resource Type:
    Masters Thesis
    Full Text:
    . Abstract approved: ______________________________________________________ Thomas J. Sharpton

  • Comparative Metagenomic Investigations Link the Functional Capacity of the Gut Microbiome to Vertebrate Physiology

    Creator:
    Armour, Courtney R.
    Abstract:
    Microscopic organisms inhabit virtually every niche on this planet, where they perform functions vital to all life on earth. Accordingly, humans host a complex community of microorganisms (i.e. the gut microbiome) that inhabit the gastrointestinal tract and modulate host physiology. Insight into the specific mechanisms through which gut microbes influence...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________ Thomas J. Sharpton Microscopic organisms inhabit virtually every niche on this planet, where

  • Ecophylogenetic Characterization of the Gut Microbiome of At-risk Companion and Food Animals

    Creator:
    Kirchoff, Nicole S.
    Abstract:
    Agricultural and companion animals are integral to our way of life as they provide us with nourishment, financial resources, transportation, and companionship. However, pets, managed animals in the agricultural industry, as well as wild populations of food animals are all subject to health and mortality risks. The gut microbiome is...
    Resource Type:
    Dissertation
    Full Text:
    approved: ______________________________________________________ Thomas J. Sharpton

  • An introduction to the analysis of shotgun metagenomic data

    Creator:
    Sharpton, Thomas J.
    Abstract:
    Environmental DNA sequencing has revealed the expansive biodiversity of microorganisms and clarified the relationship between host-associated microbial communities and host phenotype. Shotgun metagenomic DNA sequencing is a relatively new and powerful environmental sequencing approach that provides insight into community biodiversity and function. But, the analysis of metagenomic sequences is complicated...
    Resource Type:
    Article
    Full Text:
    introduction to the analysis of shotgun metagenomic data Thomas J. Sharpton* Department of Microbiology and

  • Exploring the toxigenicity and genetic similarity of Detroit Reservoir’s recurring cyanobacterial bloom in 2017 and 2018

    Creator:
    Godbole, Tejas R.
    Abstract:
    In order to understand the ability of Detroit Reservoir’s recurring cyanobacterial bloom to produce toxins, and determine the genetic similarity of the bloom from year to year, environmental samples were taken from the Detroit Reservoir bloom biomass in the summers of 2017 and 2018. DNA from these samples was sequenced,...
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Thomas Sharpton, Committee Member, representing Department of Microbiology

  • Testing monotonic trends among multiple group means against a composite null

    Creator:
    Hu, Chenxiao, Sharpton, Thomas, and Jiang, Duo
    Abstract:
    In biomedical applications, it is often of interest to test the alternative hypothesis that the means of three or more groups follow a strictly monotonic trend such as u1 > u2 > u3 against the null hypothesis that the group means are either equal or unequal but are not monotonic....
    Resource Type:
    Article
    Full Text:
    L. Kent, and Thomas J. Sharpton. A longitudinal assessment of host-microbe-parasite interactions

  • The Cathelicidin Anti-microbial peptide gene alters the mouse gut microbiome

    Creator:
    Rouches, Miles V.
    Abstract:
    The gut microbiome influences human disease including Type 2 diabetes, obesity and metabolic syndrome and interacts with the innate immune system. The human cathelicidin antimicrobial peptide (hCAMP), an important component of the innate immune system, and vitamin D and xanthohumol, a natural compound found in beer hops, regulate its expression....
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Thomas Sharpton, Committee Member, representing Microbiology