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  • Studies on the biosynthesis of capreomycin

    Creator:
    Wang, Mu, 1964-
    Resource Type:
    Masters Thesis
    Full Text:
    pharmacologically, is a second-line agent employed in combination with other antitubercular drugs. It is active

  • Biosynthesis of acivicin and 4-hydroxyacivicin

    Creator:
    Ju, Shyh-chen
    Resource Type:
    Dissertation
    Full Text:
    ) is a related antitumor agent which was isolated from the same fermentation producing acivicin and

  • Biosynthetic engineering of new pactamycins

    Creator:
    Lu, Wanli
    Abstract:
    Among the myriad of naturally occurring bioactive compounds are the aminocyclopentitol-containing natural products that represent a family of sugar-derived microbial secondary metabolites, such as the antibiotics pactamycin, allosamidin, and trehazolin. Pactamycin, a structurally unique aminocyclitol antibiotic isolated from Streptomyces pactum, consists of a 5-membered ring aminocyclitol (cyclopentitol) unit, two aromatic...
    Resource Type:
    Dissertation
    Full Text:
    antifungal activity and lower toxicity, by mutating the enoyl reductase domain of the nystatin PKS enzyme