Chordomas are uncommon neoplasms arising from notochord remnants, most commonly
occurring in the axial skeleton. Extraskeletal soft tissue chordomas are rare primary tumors, and
primary intestinal chordomas have not been reported. Herein we report 24 cases of spontaneous
primary intestinal chordomas in zebrafish, as well as 9 spontaneous vertebral chordomas....
The goal of this project was to investigate the effects and possible developmental disease implication of chronic dietary
TCDD exposure on global gene expression anchored to histopathologic analysis in juvenile zebrafish by functional genomic,
histopathologic and analytic chemistry methods. Specifically, juvenile zebrafish were fed Biodiet starter with TCDD added at...
Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing
trend. Deregulation of MYC in HCC is frequently detected and always correlated with poor
prognosis. As the zebrafish genome contains two differentially expressed zebrafish myc
orthologs, myca and mycb, it remains unclear about the oncogenicity of...
Here we report a new transgenic expression system by combination of liver-specific expression, mifepristone induction and Cre-loxP recombination to conditionally control the expression of oncogenic kras[superscript]V12. This transgenic system allowed expression of kras[superscript]V12 specifically in the liver by a brief exposure of mifepristone to induce permanent genomic recombination mediated by...
Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing trend. Deregulation of MYC in HCC is frequently detected and always correlated with poor prognosis. As the zebrafish genome contains two differentially expressed zebrafish myc orthologs, myca and mycb, it remains unclear about the oncogenicity of...
Chordomas are uncommon neoplasms arising from notochord remnants, most commonly
occurring in the axial skeleton. Extraskeletal soft tissue chordomas are rare primary tumors, and
primary intestinal chordomas have not been reported. Herein we report 24 cases of spontaneous
primary intestinal chordomas in zebrafish, as well as 9 spontaneous vertebral chordomas....
The “Cayuga syndrome” is a maternally transmitted, naturally occurring thiamine deficiency that causes 100% mortality of larval landlocked Atlantic salmon Salmo salar in several of New York's Finger Lakes, Results of multiyear studies to qualify and quantify the neurobehavioral and gross pathological signs of this condition are described, Affected sac...
The zebrafish has become an important model for cancer research. Several cancer models have
been established by transgenic expression of human or mouse oncogenes in zebrafish. Since it is
amenable to efficient transgenesis, zebrafish have immense potential to be used for studying
interaction of oncogenes and pathways at the organismal...
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, USA
Email: Bensheng Ju - Bensheng.Ju@stjude.org; JanSpitsbergen - spitsbej@onid.orst.edu
The zebrafish (Danio rerio) is emerging as a new important species for studying brain mechanisms and its deficits. Focusing on selected CNS disorders (brain cancer, epilepsy and anxiety) and using them as examples, we discuss the value of zebrafish models in translational neuroscience, and their contribution to neuroimaging, circuit-level and...
The zebrafish has become an important model for cancer research. Several cancer models have
been established by transgenic expression of human or mouse oncogenes in zebrafish. Since it is
amenable to efficient transgenesis, zebrafish have immense potential to be used for studying
interaction of oncogenes and pathways at the organismal...