Otoferlin is a C2-domain, transmembrane protein whose mutated form is responsible for the DFNB9 subtype of prelingual hearing impairment. Mutations in otoferlin cause an autosomal recessive, non-syndromic form of deafness that is characterized by auditory neuropathy/ auditory dissynchrony (AN/AD), meaning that the outer hair cells (OHCs) are normal, and the...
Higher education is being asked to address issues of quality, accountability, and transparency. Accreditation is one tool higher education institutions use to address these concerns. The purpose of this quantitative study was to analyze the impact of the new accreditation standards adopted by the Northwest Commission for Colleges and Universities...
Hexachlorophene (HCP; 2,2'-methylenebis-(3,4,6-trichlorophenol))
was developed as an antibacterial agent but was also found to induce
toxic effects in various tissues in animals and humans. Changes were
found in myelinated nerve fibers and cerebral white matter. Erythrocytes
are hemolysed in vitro. Oxidative phosphorylation is uncoupled
by HCP at concentrations less than...
Senecio jacobaea (tansy ragwort) is a common weed in the
Pacific Northwest that contains toxic pyrrolizidine alkaloids
(PAs). Jacobine, the major PA in Senecio jacobaea, was incubated
with rat liver microsomes and metabolites were isolated by high
performance liquid chromatography (HPLC) and identified by mass
spectrometric analysis. Metabolites included a...