Platelet activation uses a complex set of pathways to respond to vascular injury during hemostasis. However, thrombosis relies on the same set of pathways. Antiplatelet therapies used to prevent thrombotic events often target the P2Y₁₂ platelet receptor for inhibition but can result in bleeding diathesis or in abnormally high ADP...
Platelets undergo morphological changes essential to hemostasis upon activation at sites of vascular injury. The Rho GTPases Rac1, Cdc42, and RhoA drive these changes. Rho guanine nucleotide dissociation inhibitors (RhoGDIs) bind to the Rho GTPases to block the GDP from dissociating from the Rho GTPases, as well as anchoring the...
This thesis investigated the methods of failure in the webs of
built up girders. The beams had rectangular holes five and one-half
inches wide and seven and one-half inches high with rounded corners
in a web fourteen inches deep between flanges. The longitudinal
position of the hole edge varied from...
This paper investigates a particular bridge construction technique
which could result in a significant torsional moment. The
structural member under consideration is a prestressed concrete
girder for which no torsional consideration is made.
Torsional shear stresses can be adequately approximated for
an I-shaped girder. Laboratory model tests were performed to...
This paper investigates the proposed preliminary designs of
two gymnasiums with respect to gamma radiation shielding due to
radioactive fallout. For each building a determination is made of
the protection offered from radiation fallout. If the degree of protection
is below the minimum value set by the Office of Civil...
Two built-up wide-flange beams with several large holes in each
beam were tested to failure. Strains were measured by strain gages
at various levels, located at the ends and center of typical holes, and
deflections were measured optically at two points on each beam.
Lateral bracing was provided to prevent...