Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
Full Text:
L. Clark, TomDarden, Paul
Emsley, Victoria A. Feher, Zukang Feng, Colin R. Groom, Seth F. Harris
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
Full Text:
,14 TomDarden,15 Paul Emsley,16 Victoria A. Feher,17,* Zukang Feng,5,6 Colin R. Groom,18,*
Seth F
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
Published May 1987. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Globalisation in the retail sector is transforming food value chains by driving consolidation in the industry and extending supply chains across the globe. Globalisation enables retailers to benefit from economies of scale and cheaper production in foreign locations. However, food markets themselves are increasingly responding to local consumer preferences. In...
Apologia is a rhetorical genre of self-defense. As such, apologetic discourse
involves a response to an attack upon an individual's character or worth as a human being.
Los Angeles Police Detective Mark Fuhrman encountered such a attack during the 0.J.
Simpson murder trial. The purpose of this analysis is to...
The purpose of this study was to determine the impact a narrative reflecting team experience has on counselor self-efficacy. Through a quasi-experimental design, the use of a narrative reflecting team supervision model was compared to supervision as usual with graduate counseling students (N=12). The Counselor Self-Estimate Inventory (COSE) was chosen...
The study investigates the influence of the self-reference
effect upon the amount of main and subordinate ideas which older
adults can recall and recognize after viewing the television
documentary entitled, The Xinquana: Aborigines of South America.
The participants are native English-speaking Americans who are
50 years old or older. The...
Although perceived-risk curriculum, that is, where the learner experiences effects of eustress (positive stress), has been used in Arts or outdoor activities, it has not been used in school classrooms. Milkman’s 1996 studies of after-school Project Self Discovery demonstrated that at-risk students lessened their adverse risky behaviors, such as substance...
A growing body of literature associates transgender and gender non-conforming (TGNC) identity with adverse mental and emotional health outcomes. Only a handful of studies have been conducted using population-based samples of adolescents to study mental health outcomes in TGNC youth (e.g., Eisenberg et al., 2017; Perez-Brumer, Day, Russell, & Hatzenbuehler,...
....................................................................................................... 82
DEDICATION
This work is dedicated to my husband, Tom
Life on Earth intimately depends on the function of countless proteins. For the majority of studied proteins, function absolutely depends on conformation (i.e. 3-dimensional shape in solution). The exact nature of how a protein goes from an unfolded linear polypeptide chain to an organized folded molecule is still not known,...
Greater sage-grouse (Centrocercus urophasianus) were once found in most grassland and sagebrush (Artemisia spp.) habitats east of the Cascades in Oregon. European settlement and conversion of sagebrush steppe into agricultural production led to extirpation of the species in the Columbia Basin by the early part of the 1900s, but sagebrush...
Published December 2004. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
This dissertation has two objectives. The first objective is to determine where best to situate the study of mentoring (i.e. the 'making of scientists') on the landscape of the history of science and science studies. This task is accomplished by establishing mentoring studies as a link between the robust body...