Background:
In the Ganges Delta, chronic arsenic poisoning is a health concern affecting millions of people who rely on groundwater as their potable water source. The prevalence of anemia is also high in this region, particularly among women. Moreover, arsenic is known to affect heme synthesis and erythrocytes and the...
BACKGROUND: Arsenic, a common groundwater pollutant, is associated with adverse reproductive health but few
studies have examined its effect on maternal health.
METHODS: A prospective cohort was recruited in Bangladesh from 2008–2011 (N = 1,458). At enrollment (<16 weeks
gestational age [WGA]), arsenic was measured in personal drinking water using...
BACKGROUND: Chronic exposure to arsenic is associated with skin lesions. However, it is not known whether reducing arsenic exposure will improve skin lesions.
OBJECTIVE: We evaluated the association between reduced arsenic exposures and skin lesion recovery over time.
METHODS: A follow-up study of 550 individuals was conducted in 2009-2011 on...
Exposure to arsenic early in life has been associated with increased risk of several chronic diseases and is believed to alter epigenetic programming in utero. In the present study, we evaluate the epigenome-wide association of arsenic exposure in utero and DNA methylation in placenta (n=37), umbilical artery (n=45) and human...
Under-5 mortality has decreased globally, but millions of children still die every year. In Bangladesh, respiratory infection and diarrheal disease remain leading causes of morbidity and mortality for children under-5, despite incredible progress in the past three decades. Immune system development begins in utero and continues into adulthood. Toxic environmental...
Bangladesh is a developing country with burdens of environmental pollution and disparities in maternal and child health. Arsenic, manganese, and lead are pervasive environmental contaminants throughout Bangladesh with major exposures through drinking water and ambient pollution. Chronic exposures to arsenic, manganese, and lead in sensitive populations such as pregnant women,...
BACKGROUND: The relationship between arsenic and birth weight is not well understood.
OBJECTIVE: To evaluate the causal relationship between prenatal arsenic exposure and birth weight considering the potential mediation effects of gestational age (GA) and maternal weight gain (MWG) during pregnancy using structural equation models (SEMs).
METHODS: A prospectively enrolled...
Abstract: Background: Chronic exposure to arsenic in drinking water is associated with increased risk of type 2 diabetes mellitus (T2DM) but the underlying molecular mechanism remains unclear.
Objectives: This study evaluated the interaction between single nucleotide polymorphisms (SNPs) in genes associated with diabetes and arsenic exposure in drinking water on...
Exposure to arsenic early in life has been associated with increased risk of several chronic diseases and is believed to alter epigenetic programming in utero. In the present study, we evaluate the epigenome-wide association of arsenic exposure in utero and DNA methylation in placenta (n = 37), umbilical artery (n...
Mercury and arsenic are known developmental toxicants and environmental exposures are ubiquitous worldwide from natural and anthropogenic sources. Prenatal exposure to both contaminants are independently associated with adverse perinatal health outcomes and latent disease risk that could be in part mediated by epigenetic reprogramming events. Fetal programming events involving DNA...