Eight spontaneous orocutaneous papillomas of adult, wild-caught brown bullheads Ictalurus
nebulosus and 4 anatomically matching control tissue samples were examined by electron
microscopy. Ultrastructural characteristics of normal and neoplastic Malpighian epithelial cells were
compared and neoplastic cells were described. Normal Malpighian epithelial cells of brown bullheads
were similar to those...
Here we report a new transgenic expression system by combination of liver-specific expression,
mifepristone induction and Cre-loxP recombination to conditionally control the expression of oncogenic
kras[superscript]V12. This transgenic system allowed expression of kras[superscript]V12 specifically in the liver by a brief exposure
of mifepristone to induce permanent genomic recombination mediated by...
Full Text:
expression in transgenic zebrafish
Anh Tuan Nguyen
1, 2
, Vivien Koh
1
, Jan M. Spitsbergen
2
During the past decade the zebrafish has emerged as a leading model for mechanistic cancer
research due to its sophisticated genetic and genomic resources, its tractability for tissue
targeting of transgene expression, its efficiency for forward genetic approaches to cancer model
development, and its cost-effectiveness for enhancer and suppressor screens...
Chordomas are uncommon neoplasms arising from notochord remnants, most commonly
occurring in the axial skeleton. Extraskeletal soft tissue chordomas are rare primary tumors, and
primary intestinal chordomas have not been reported. Herein we report 24 cases of spontaneous
primary intestinal chordomas in zebrafish, as well as 9 spontaneous vertebral chordomas....
Full Text:
Zebrafish
(Danio rerio)
Cooper, T. K., Murray, K. N., Spagnoli, S., & Spitsbergen, J. M. (2014). Primary
Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing
trend. Deregulation of MYC in HCC is frequently detected and always correlated with poor
prognosis. As the zebrafish genome contains two differentially expressed zebrafish myc
orthologs, myca and mycb, it remains unclear about the oncogenicity of...
Full Text:
Mutation
Sun, L., Nguyen, A. T., Spitsbergen, J. M., & Gong, Z. (2015). Myc-Induced Liver
Tumors in
Here we report a new transgenic expression system by combination of liver-specific expression,
mifepristone induction and Cre-loxP recombination to conditionally control the expression of oncogenic
kras[superscript]V12. This transgenic system allowed expression of kras[superscript]V12 specifically in the liver by a brief exposure
of mifepristone to induce permanent genomic recombination mediated by...
Full Text:
Anh Tuan Nguyen
Vivien Koh
Jan M. Spitsbergen
Zhiyuan
The goal of this project was to investigate the effects and possible developmental disease implication of chronic dietary
TCDD exposure on global gene expression anchored to histopathologic analysis in juvenile zebrafish by functional genomic,
histopathologic and analytic chemistry methods. Specifically, juvenile zebrafish were fed Biodiet starter with TCDD added at...
Full Text:
, Spitsbergen JM, Cariou R, Huang C-Y, Jiang N, et al. (2014)
Histopathologic Alterations Associated with
Chordomas are uncommon neoplasms arising from notochord remnants, most commonly
occurring in the axial skeleton. Extraskeletal soft tissue chordomas are rare primary tumors, and
primary intestinal chordomas have not been reported. Herein we report 24 cases of spontaneous
primary intestinal chordomas in zebrafish, as well as 9 spontaneous vertebral chordomas....
Chordomas are uncommon neoplasms arising from notochord remnants, most commonly
occurring in the axial skeleton. Extraskeletal soft tissue chordomas are rare primary tumors, and
primary intestinal chordomas have not been reported. Herein we report 24 cases of spontaneous
primary intestinal chordomas in zebrafish, as well as 9 spontaneous vertebral chordomas....
The goal of this project was to investigate the effects and possible developmental disease implication of chronic dietary
TCDD exposure on global gene expression anchored to histopathologic analysis in juvenile zebrafish by functional genomic,
histopathologic and analytic chemistry methods. Specifically, juvenile zebrafish were fed Biodiet starter with TCDD added at...
