Platelet activation uses a complex set of pathways to respond to vascular injury during hemostasis. However, thrombosis relies on the same set of pathways. Antiplatelet therapies used to prevent thrombotic events often target the P2Y₁₂ platelet receptor for inhibition but can result in bleeding diathesis or in abnormally high ADP...
Platelets undergo morphological changes essential to hemostasis upon activation at sites of vascular injury. The Rho GTPases Rac1, Cdc42, and RhoA drive these changes. Rho guanine nucleotide dissociation inhibitors (RhoGDIs) bind to the Rho GTPases to block the GDP from dissociating from the Rho GTPases, as well as anchoring the...
My dissertation concerns two separate issues. The first issue is examined in Essay One, and the second issue is examined in Essays Two and Three.
The first essay develops an economic model of the determination of the rental rate of leased farmland in the United States. Particular attention is placed...
In eastern boundary current upwelling ecosystems, mesoscale circulation features such as eddies and upwelling filaments play a prominent role in the transfer of water and the associated plankton from the productive nearshore to the oligotrophic deep sea. The relationship between mesoscale circulation, zooplankton distributions, and the across-shelf transport of coastal...
The electrical and optical properties of semi-insulating, epitaxial and ion-implanted GaAs and InP have been characterized and analyzed. Electron and hole traps in semi-insulating GaAs and InP, with activation energies ΔE[subscript T] ranging from 0.16 ± 0.01 to 0.98 ± 0.01 eV, have been detected and characterized by Photo-Induced Current...
Two built-up wide-flange beams with several large holes in each
beam were tested to failure. Strains were measured by strain gages
at various levels, located at the ends and center of typical holes, and
deflections were measured optically at two points on each beam.
Lateral bracing was provided to prevent...
This paper investigates the proposed preliminary designs of
two gymnasiums with respect to gamma radiation shielding due to
radioactive fallout. For each building a determination is made of
the protection offered from radiation fallout. If the degree of protection
is below the minimum value set by the Office of Civil...
This paper investigates a particular bridge construction technique
which could result in a significant torsional moment. The
structural member under consideration is a prestressed concrete
girder for which no torsional consideration is made.
Torsional shear stresses can be adequately approximated for
an I-shaped girder. Laboratory model tests were performed to...