Index Catalog // ScholarsArchive@OSU

Human in vivo Pharmacokinetics of [¹⁴C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Micro-Dosing

Creator:: Madeen, Erin, Corley, Richard A., Crowell, Susan, Turteltaub, Kenneth, Ognibene, Ted, Malfatti, Mike, McQuistan, Tammie J., Garrard, Mary, Sudakin, Dan, and Williams, David E.
Abstract:: Dibenzo(def,p)chrysene (DBC), (also known as dibenzo[a,l]pyrene), is a high molecular weight polycyclic aromatic hydrocarbon (PAH) found in the environment, including food, produced by the incomplete combustion of hydrocarbons. DBC, classified by IARC as a 2A probable human carcinogen, has a relative potency factor (RPF) in animal cancer models 30-fold higher...
Resource Type:: Article

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Creator:: Madeen, Erin
Abstract:: The objective of this work is to add to the body of translational data between high dose animal model research and the environmentally relevant human metabolism of the persistent pollutant dibenzo[def,p]chrysene (DBC). We furthered the knowledge of gene/exposure interactions by determining the carcinogenesis risk based on Cyp1b1 genotype following in...
Resource Type:: Dissertation
Full Text:: across genotypes. In addition, sensitive accelerator mass spectrometry (AMS) was

Analysis of electrophilic compounds using an electron monochromator : mass spectrometer system

Creator:: Mazurkiewicz, Paul H.
Resource Type:: Dissertation
Full Text:: Dr. Max Deinzer and would like to thank the entire mass spectrometry group for their aid and

Characterization of UV-crosslinked protein-nucleic acid interfaces by Maldi MS and ESI MS/MS

Creator:: Gafken, Philip R.
Resource Type:: Dissertation
Full Text:: spectrometry. It used matrix-assisted Iaser-desorption ionization mass spectrometry (MALDI MS) to tentatively

A new technique for high performance tandem time-of-flight mass spectrometry

Creator:: Katz, Daniel Louis
Abstract:: The main result of this written dissertation is a mathematical solution to the problem of multiplex recording for high performance tandem time-of-flight mass spectrometry. The prescription is to use a time-lag accelerator in the second stage to match the ion optical properties of the decay fragments to the requirements of...
Resource Type:: Dissertation
Full Text:: Technique for High Performance Tandem Time-of-Flight Mass Spectrometry. Abstract approved. Douglas F

From fossils to phylogenies

Creator:: Goodwin, Baylee N., Besser, August D., and Ramsey, Stephen A.
Abstract:: The research question address in this study is, “To what extent will the use of hands-on activities for introducing concepts in bioinformatics promote student engagement in after-school STEM club settings?” It is hypothesized that high school students' engagement in hands-on bioinformatics activities promotes their awareness of, and interest in, STEM...
Resource Type:: Learning Object and Presentation
Full Text:: ability to discuss and debate the ethics of scientific endeavors. 2. Mass Spectrometry Activity- Using

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Creator:: Huang, Lin
Abstract:: Oxidative stress is deﬁned as an imbalance that favors the production of reactive oxygen species (ROS) over an organism's antioxidant defense. ROS have the ability to damage, either directly or indirectly, biomolecules including DNA, proteins, carbohydrates, and lipids. Various pathological conditions and environmental and chronic diseases have been associated with...
Resource Type:: Dissertation
Full Text:: memory. Firstly, we explored the applicability of travelling wave ion mobility mass spectrometry

Alkylation of peptides and proteins by S-(2-chloroethyl)glutathione and characterization of adducts by mass spectrometry

Creator:: Erve, John C. L.
Abstract:: Glutathione, a ubiquitous intracellular tripeptide, protects cells by reacting with electrophiles and radicals that can damage cellular macromolecules. However, glutathione conjugation is now recognized as one mechanism by which drugs and xenobiotics can also be converted to reactive intermediates having toxic consequences to cells. The halogenated alkane 1,2-dichloroethane forms S-(2-chloroethyl)...
Resource Type:: Dissertation
Full Text:: and Proteins by S-(2-chloroethyl) glutathione and Characterization of Adducts by Mass Spectrometry

Time-of-flight scattering and recoil spectrometry (TOF-SARS) applied to molecular liquid surfaces : a new approach to surface composition and orientation

Creator:: Gannon, Thomas J.
Abstract:: In spite of their importance in many systems, liquid surfaces have been explored at the microscopic level to a much lesser extent than solids. Most surface analysis must take place in vacuum, a major drawback for liquids. The technique of time-of-flight scattering and recoil spectrometry (TOF-SARS) has been applied to...
Resource Type:: Dissertation
Full Text:: surfaces in both ion scattering spectrometry (ISS) 7 and secondary ion mass spectrometry (SIMS). Both

Time-of-flight direct recoil spectrometry : application to liquid surfaces and steps toward quantification

Creator:: Tassotto, Michael
Abstract:: Liquid surfaces are very abundant in nature. Despite the importance of the liquid interface in general, experimental molecular-level data was almost completely lacking prior to the last decade and a half. The intent of this work is to provide a means by which experimental data on the composition of liquid...
Resource Type:: Dissertation
Full Text:: ion mass spectrometry (SIMS) represents the low-energy end of ISS, performing elemental analysis by

ScholarsArchive@OSU

Human in vivo Pharmacokinetics of [¹⁴C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Micro-Dosing

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Analysis of electrophilic compounds using an electron monochromator : mass spectrometer system

Characterization of UV-crosslinked protein-nucleic acid interfaces by Maldi MS and ESI MS/MS

A new technique for high performance tandem time-of-flight mass spectrometry

From fossils to phylogenies

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Alkylation of peptides and proteins by S-(2-chloroethyl)glutathione and characterization of adducts by mass spectrometry

Time-of-flight scattering and recoil spectrometry (TOF-SARS) applied to molecular liquid surfaces : a new approach to surface composition and orientation

Time-of-flight direct recoil spectrometry : application to liquid surfaces and steps toward quantification

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