Index Catalog // ScholarsArchive@OSU

Proteomics-driven Antigen Discovery for Development of Vaccines Against Gonorrhea

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., Gafken, Philip R., Soge, Olusegun O., Holmes, King K., Jerse, Ann E., Unemo, Magnus, and Sikora, Aleksandra E.
Abstract:: Expanding efforts to develop preventive gonorrhea vaccines is critical because of the dire possibility of untreatable gonococcal infections. Reverse vaccinology, which includes genome and proteome mining, has proven very successful in the discovery of vaccine candidates against many pathogenic bacteria. However, progress with this approach for a gonorrhea vaccine remains...
Resource Type:: Article
Full Text:: Society for Biochemistry and Molecular Biology, Inc. This paper is available on line at http

Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr(-/-) mice by targeting the TGFβ-Smad3 pathway

Creator:: Lytle, Kelli A., Depner, Christopher M., Wong, Carmen P., and Jump, Donald B.
Abstract:: DHA (22:6,ω3), but not EPA (20:5,ω3), attenuates Western diet (WD)-induced hepatic fibrosis in a Ldlr[superscript −/−] mouse model of nonalcoholic steatohepatitis. We examined the molecular basis for the differential effect of dietary EPA and DHA on WD-induced hepatic fibrosis. DHA was more effective than EPA at preventing WD-induced effects on...
Resource Type:: Article

A Systematic Investigation of Structure/Function Requirements for the Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop of High-density Lipoprotein

Creator:: Gu, Xiaodong, Wu, Zhiping, Huang, Ying, Wagner, Matthew A., Baleanu-Gogonea, Camelia, Mehl, Ryan A., Buffa, Jennifer A., DiDonato, Anthony J., Hazen, Leah B., Fox, Paul L., Gogonea, Valentin, Parks, John S., DiDonato, Joseph A., and Hazen, Stanley L.
Abstract:: The interaction of lecithin-cholesterol acyltransferase (LCAT) with apolipoprotein A-I (apoA-I) plays a critical role in highdensity lipoprotein (HDL) maturation.Wepreviously identified a highly solvent-exposed apoA-I loop domain (Leu¹⁵⁹–Leu¹⁷⁰) in nascent HDL, the so-called “solar flare” (SF) region, and proposed that it serves as an LCAT docking site (Wu, Z., Wagner, M....
Resource Type:: Article
Full Text:: . 6386 –6395, March 18, 2016 © 2016 by The American Society for Biochemistry and Molecular Biology, Inc

Interactions of yeast dynein with dynein light chain and dynactin: General implications for intrinsically disordered duplex scaffolds in multi-protein assemblies

Creator:: Jie, Jing, Löhr, Frank, and Barbar, Elisar
Abstract:: Intrinsically disordered protein (IDP) duplexes composed of two IDP chains cross-linked by bivalent partner proteins form scaffolds for assembly of multiprotein complexes. The N-terminal domain of dynein intermediate chain (N-IC) is one such IDP that forms a bivalent scaffold with multiple dynein light chains including LC8, a hub protein that...
Resource Type:: Article
Full Text:: (16), 35 kDa for β-lactoglobulin, and 13.7 kDa for ribonuclease A. Computed molecular weights of

Muscle Segment Homeobox Genes Direct Embryonic Diapause by Limiting Inflammation in the Uterus

Creator:: Cha, Jeeyeon, Burnum-Johnson, Kristin E., Bartos, Amanda, Li, Yingju, Baker, Erin S., Tilton, Susan C., Webb-Robertson, Bobbie-Jo M., Piehowski, Paul D., Monroe, Matthew E., Jegga, Anil G., Murata, Shigeo, Hirota, Yasushi, and Dey, Sudhansu K.
Abstract:: Embryonic diapause is a reproductive strategy widespread in the animal kingdom. This phenomenon is defined by a temporary arrest in blastocyst growth and metabolic activity within a quiescent uterus without implantation until the environmental and maternal milieu become favorable for pregnancy to progress. We found that uterine Msx expression persists...
Resource Type:: Article

Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice

Creator:: Tripathy, Sasmita, Lytle, Kelli A., Stevens, Robert D., Bain, James R., Newgard, Christopher B., Greenberg, Andrew S., Huang, Li-Shin, and Jump, Donald B.
Abstract:: Nonalcoholic fatty liver disease is a major public health concern in the obese and type 2 diabetic populations. The high-fat lard diet induces obesity and fatty liver in C57BL/6J mice and suppresses expression of the PPAR-target gene, FA elongase 5 (Elovl5). Elovl5 plays a key role in MUFA and PUFA...
Resource Type:: Article

Ribonucleotide Reductase Association with Mammalian Liver Mitochondria

Creator:: Chimploy, Korakod, Song, Shiwei, Wheeler, Linda J., and Mathews, Christopher K.
Abstract:: Deoxyribonucleoside triphosphate pools in mammalian mitochondria are highly asymmetric, and this asymmetry probably contributes toward the elevated mutation rate for the mitochondrial genome as compared with the nuclear genome. To understand this asymmetry, we must identify pathways for synthesis and accumulation of dNTPs within mitochondria. We have identified ribonucleotide reductase...
Resource Type:: Article
Full Text:: Christopher K. Mathews3 From the Department of Biochemistry and Biophysics, Oregon State University

Omega-3 Fatty Acid Supplementation and Cardiovascular Disease

Creator:: Jump, Donald B., Depner, Christopher M., and Tripathy, Sasmita
Abstract:: Epidemiological studies on Greenland Inuits in the 1970s and subsequent human studies have established an inverse relationship between the ingestion of omega-3 fatty acids [C₂₀₋₂₂ ω3 polyunsaturated fatty acids (PUFA)], blood levels of C₂₀₋₂₂ ω3 PUFA and mortality associated with cardiovascular disease [CVD]. C₂₀₋₂₂ ω3 PUFA have pleiotropic effects on...
Resource Type:: Article

Elovl5 Regulates the mTORC2-Akt-FOXO1 Pathway by Controlling Hepatic cis-Vaccenic Acid Synthesis in Diet-Induced Obese Mice

Creator:: Tripathy, Sasmita and Jump, Donald B.
Abstract:: Elevated hepatic expression of fatty acid elongase-5 (Elovl5) induces FoxO1 phosphorylation, lowers FoxO1 nuclear content and suppresses expression of genes involved in gluconeogenesis. In this report we define the molecular and metabolic basis of Elovl5 control of FoxO1 phosphorylation. Adenoviral-mediated (Ad-Elovl5) induction of hepatic Elovl5 in diet induced obese-glucose intolerant...
Resource Type:: Article
Full Text:: the molecular and metabolic basis of Elovl5 control of FoxO1 phosphorylation. Adenoviral-mediated

Yeast POS5 NADH Kinase: Effects of a Mitochondrial Mutator Mutation on Mitochondrial Nucleotides

Creator:: Wheeler, Linda J. and Mathews, Christopher K.
Abstract:: Saccharomyces cerevisiae contains three NAD⁺/NADH kinases, one of which is localized in mitochondria and phosphorylates NADH in preference to NAD⁺. Strand et al (Euk. Cell 2:809 (2003)) reported that a yeast mutation in POS5, which encodes the mitochondrial NADH kinase, is a mutator, specific for mitochondrial genes. Because of the...
Resource Type:: Article
Full Text:: * Linda J. Wheeler and Christopher K. Mathews1 From the Department of Biochemistry and Biophysics

ScholarsArchive@OSU

Proteomics-driven Antigen Discovery for Development of Vaccines Against Gonorrhea

Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr(-/-) mice by targeting the TGFβ-Smad3 pathway

A Systematic Investigation of Structure/Function Requirements for the Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop of High-density Lipoprotein

Interactions of yeast dynein with dynein light chain and dynactin: General implications for intrinsically disordered duplex scaffolds in multi-protein assemblies

Muscle Segment Homeobox Genes Direct Embryonic Diapause by Limiting Inflammation in the Uterus

Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice

Ribonucleotide Reductase Association with Mammalian Liver Mitochondria

Omega-3 Fatty Acid Supplementation and Cardiovascular Disease

Elovl5 Regulates the mTORC2-Akt-FOXO1 Pathway by Controlling Hepatic cis-Vaccenic Acid Synthesis in Diet-Induced Obese Mice

Yeast POS5 NADH Kinase: Effects of a Mitochondrial Mutator Mutation on Mitochondrial Nucleotides

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