WLBU2 is an engineered cationic amphiphilic peptide that targets Gram-positive and Gram-negative bacteria, and envelopes endotoxin while avoiding other cell types. The exact mechanism of how WLBU2 targets, binds, and disrupts bacterial cell membranes is still not completely known. Thus, the overall goal of this investigation is to determine the...
Nalidixic acid and its derivatives act through inhibition of
bacterial DNA gyrase activity. Recently there have been a series of
papers reporting the antibacterial activity against three different
types of bacteria (S. aureus, E. coli and P. aeruginosa) by a series
of 1,4-dihydro-4-oxoquinoline (or 1,8-naphthyridine) 3-carboxylic
acids. Consistent biological data...
β-chitin/chitosan extracted from newly utilized jumbo squid (Dosidicus gigas) pens were investigated in respect to their physicochemical properties, polymeric structures, deacetylation and depolymerization characteristics, and antioxidant and antibacterial activities. These functional properties were further compared with α-chitin/chitosan prepared from shrimp shells. Due to the low mineral content (< 1%) and...