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Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

Creator:: Grochowski, Laura L.
Abstract:: Molecular genetic and enzymological techniques have been employed to study secondary metabolite biosynthesis. These investigations have focused on two projects: the cloning and heterologous expression of biosynthetic gene clusters from unculturable marine organisms and the characterization of individual enzymes involved in the biosynthesis of the antifungal agent blasticidin S. The...
Resource Type:: Dissertation
Full Text:: involved in the biosynthesis of the antifungal agent blasticidin S. The marine environment is proving to

Itraconazole formation using supercritical carbon dioxide

Creator:: Tang, Yi-Min
Resource Type:: Masters Thesis
Full Text:: Table 1.1. Itraconazole is an anti-fungal agent, which has therapeutic effects for patients who have

Synthetic studies n bioactive natural products. Part I, An approach towards the nootrophic agent huperzine A. Part II, Synthesis of the tricarbonyl subunit of rapamycin

Creator:: Jeffrey, Scott C.
Resource Type:: Dissertation
Full Text:: approach towards the nootrophic agent huperzine A. Part II, Synthesis of the tricarbonyl subunit of

Total synthesis of phorboxazole A

Creator:: Lee, Tae Hee
Abstract:: The total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, is described. Both a palladium(II)-mediated and a palladium(II)-catalyzed intramolecular alkoxycarbonylation were used as key steps for the preparation of the two cis-2,6-disubstituted tetrahydropyran rings (C22-C26 and C11-C15) of phorboxazole A. The synthesis used a convergent approach involving...
Resource Type:: Dissertation

Studies on the biosynthesis of capreomycin

Creator:: Wang, Mu, 1964-
Resource Type:: Masters Thesis
Full Text:: pharmacologically, is a second-line agent employed in combination with other antitubercular drugs. It is active

Synthetic approaches to the tricarbonyl subunit of rapamycin

Creator:: LaMunyon, James B.
Abstract:: Rapamycin (5) was isolated in 1975 from the soil bacteria Streptomyces hygroscopicus and its structure was determined from spectroscopic techniques and an x-ray crystallographic analysis. Although it was initially found to exhibit antibiotic activity, it was subsequently shown to possess potent immunosuppressive activity as well. Three approaches to the synthesis...
Resource Type:: Masters Thesis
Full Text:: promising immunosuppressive agent, was isolated from the bacteria Streptomyces tsukukaenis in 1987.12 This

Studies toward the total synthesis of sanglifehrin A

Creator:: Suttisintong, Khomson
Abstract:: Studies toward synthesis of subunits of sanglifehrin A, an immunosuppressant featuring a highly substituted [5,5]-spirolactam moiety as well as a 22-membered macrocycle are described. The macrolactone contains a peptidic backbone characterized by an unusual [beta]-substituted (S)-piperazic acid and (S)-m-hydroxyphenylalanine units. These studies resulted in the synthesis of advanced intermediate 358...
Resource Type:: Dissertation

Synthetic studies toward the total synthesis of amphidinolide B₁

Creator:: Zhang, Wei
Abstract:: Amphidinolide B₁ is one of the most potent cytotoxic compounds in the amphidinolide family. Its bioactivity and intriguing structure has drawn attention from synthetic chemists. Although numerous synthetic efforts toward the total synthesis of amphidinolide B₁ have been published, it still remains an unconquered synthetic target. One of the unique...
Resource Type:: Dissertation

Biosynthesis of acivicin and 4-hydroxyacivicin

Creator:: Ju, Shyh-chen
Resource Type:: Dissertation
Full Text:: ) is a related antitumor agent which was isolated from the same fermentation producing acivicin and

Synthetic studies on natural products : Part I. The total synthesis of ±-euonyminol and ±-3,4-dideoxymaytol : Part II. The absolute configuration and enantioselective synthesis of curacin A

Creator:: Kim, Tae-Seong
Resource Type:: Dissertation
Full Text:: A (14), a potent antimitotic agent from the cyanobacterium Lyngbya majuscula is described. The

ScholarsArchive@OSU

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

Itraconazole formation using supercritical carbon dioxide

Synthetic studies n bioactive natural products. Part I, An approach towards the nootrophic agent huperzine A. Part II, Synthesis of the tricarbonyl subunit of rapamycin

Total synthesis of phorboxazole A

Studies on the biosynthesis of capreomycin

Synthetic approaches to the tricarbonyl subunit of rapamycin

Studies toward the total synthesis of sanglifehrin A

Synthetic studies toward the total synthesis of amphidinolide B₁

Biosynthesis of acivicin and 4-hydroxyacivicin

Synthetic studies on natural products : Part I. The total synthesis of ±-euonyminol and ±-3,4-dideoxymaytol : Part II. The absolute configuration and enantioselective synthesis of curacin A

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