Index Catalog // ScholarsArchive@OSU

Method development for extraction and purification of dermal RNA from FVB/Nmice treated with environmental PAH mixtures

Creator:: Larkin, Andrew, Siddens, Lisbeth, and Krueger, Sharon
Abstract:: Epidermal RNA samples from FVB/N mice treated with PAH standards and environmental PAH mixtures were harvested and purified using Trizol extraction and RNeasy mini prep kit purification. Epidermal RNA integrity was low (RIN mean 3.5), indicating significant RNA degradation and the need to modify handling, collection, and processing of skin...
Resource Type:: Undergraduate Thesis and Presentation

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Creator:: You, Hyekyoung Hannah
Abstract:: Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...
Resource Type:: Honors College Thesis
Full Text:: Environmental and Molecular Toxicology/Linus Pauling Institute William M. Baird, Committee Member

Genome scale transcriptome analysis and development of reporter systems for studying shoot organogenesis in poplar

Creator:: Bao, Yanghuan
Abstract:: Vegetative propagation allows the amplification of selected genotypes for research, breeding, and commercial planting. However, efficient in vitro regeneration and genetic transformation remains a major obstacle to research and commercial application in many plant species. Our aims are to improve knowledge of gene regulatory circuits important to meristem organization, and...
Resource Type:: Masters Thesis

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Creator:: Courter, Lauren A.
Abstract:: Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...
Resource Type:: Dissertation
Full Text:: abundance from my God. CONTRIBUTION OF AUTHORS Dr. William M. Baird provided guidance, advice and

Precursors for mitochondrial DNA replication : metabolic sources and relations to mutagenesis and human diseases

Creator:: Song, Shiwei
Abstract:: It is well known that the mitochondrial genome has a much higher spontaneous mutation rate than the nuclear genome. mtDNA mutations have been identified in association with many diseases and aging. mtDNA replication continues throughout the cell cycle, even in post-mitotic cells. Therefore, a constant supply of nucleotides is required...
Resource Type:: Dissertation
Full Text:: , William M. Baird, Michael I. Schimerlik, and Bruce E. Coblentz for taking time with this thesis. I would

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Creator:: Castro, David J.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a re-emerging class of environmental pollutants. The persistent nature of these highly toxic compounds along with their ubiquity in the environment creates an unavoidable route of exposure. The developing fetus and neonate are a particularly susceptible population due to their incomplete complement of xenobiotic metabolizing...
Resource Type:: Dissertation
Full Text:: in chapter 3. Drs. William M. Baird and Sharon K. Krueger assisted in the manuscript preparation of

The relationship between self-actualization and an individualized field centered undergraduate teacher-education program

Creator:: Watson, Herbert Witherspoon
Resource Type:: Dissertation
Full Text:: committee -- Dr. William Crooks, Dr. Dwight Baird, and Dr. Grant Blanch. Thanks is also extended to my

Measuring in situ biotransformation in BTEX-contaminated groundwater

Creator:: Alumbaugh, Robert E.
Abstract:: Benzylsuccinate (BSA), methylbenzylsuccinate (methylBSA), and ethylbenzylsuccinate (ethylBSA) are unambiguous anaerobic biotransformation products from toluene, xylenes, and ethylbenzene decay, respectively, and may be used to indicate intrinsic bioremediation is occurring at hydrocarbon-contaminated sites. In order to improve upon current methods that detect and quantify anaerobic hydrocarbon metabolites in field samples, solid-phase-extraction...
Resource Type:: Masters Thesis
Full Text:: chromatography advice and for being a strong advocate, and Dr. William Baird for his continuous encouragement and

Trace analysis of halogenated polycyclic aromatic hydrocarbons from an electronic waste recycling area and Guangzhou, China

Creator:: Gonzales, Leah R.
Abstract:: Halogenated Polycyclic Aromatic Hydrocarbons (X-PAHs) are ubiquitous contaminants that are thought to be generated by processes such as chemical industries and incomplete combustion, including waste incineration and electronic waste (e-waste) burning. X-PAHs are a concern for environmental and human health because they are toxic, mutagenic, and are expected to be...
Resource Type:: Masters Thesis
Full Text:: graduate committee: Dr. William Baird, Dr. Jennifer Field, and Dr. Vincent Remcho. I would also like to

Determination of fluorochemicals in waste-dominated aqueous systems

Creator:: Huset, Carin A.
Abstract:: While fluorochemicals have been detected all over the world and in wastewater treatment plants, the effect of wastewater effluent on the receiving waters has not been evaluated. In the first study, the mass flow of fluorochemicals emanating from wastewater treatment plants along the Glatt River in Switzerland was evaluated. The...
Resource Type:: Dissertation
Full Text:: would like to thank my graduate committee, Drs. William Baird, Douglas Barofsky, Jennifer Field

ScholarsArchive@OSU

Method development for extraction and purification of dermal RNA from FVB/Nmice treated with environmental PAH mixtures

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Genome scale transcriptome analysis and development of reporter systems for studying shoot organogenesis in poplar

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Precursors for mitochondrial DNA replication : metabolic sources and relations to mutagenesis and human diseases

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

The relationship between self-actualization and an individualized field centered undergraduate teacher-education program

Measuring in situ biotransformation in BTEX-contaminated groundwater

Trace analysis of halogenated polycyclic aromatic hydrocarbons from an electronic waste recycling area and Guangzhou, China

Determination of fluorochemicals in waste-dominated aqueous systems

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