Index Catalog // ScholarsArchive@OSU

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Creator:: Courter, Lauren A.
Abstract:: Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...
Resource Type:: Dissertation
Full Text:: abundance from my God. CONTRIBUTION OF AUTHORS Dr. William M. Baird provided guidance, advice and

DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

Creator:: Hooven, Louisa Ada
Abstract:: Exposure to polycyclic aromatic hydrocarbons such as benzo[a]pyrene (B[a]P) has been determined to be a risk factor for various forms of human cancer. PAH DNA adducts have been shown to cause mutations, but carcinogenesis is also accompanied by alterations in gene expression. Inhibiting individual cytochrome P450s could clarify the interaction...
Resource Type:: Dissertation
Full Text:: : William M. Baird Exposure to polycyclic aromatic hydrocarbons such as benzo[a]pyrene (B[a]P) has been

Adapting computer science technologies to bridge critical gaps in proposed Tox21 risk assessment programs

Creator:: Larkin, Andrew
Abstract:: In 2004 the National Toxicology Program published an article describing their intent to pursue toxicology testing and risk assessment practices solely reliant on high throughput in vitro datasets and in silico modeling for dose-response assessments. Support and contributions form regulatory agencies and a significant portion of the life sciences community...
Resource Type:: Dissertation
Full Text:: approved: ______________________________________________________ David E. Williams William M. Baird

A comparison between Portland Community College and Seattle Community College for determination of organizational efficiency

Creator:: Shaffer, Mildred Johnson
Resource Type:: Dissertation
Full Text:: Determination of Organizational Efficiency'Redacted for privacy Abstract approved: DwiA C. Baird Community

Method development for extraction and purification of dermal RNA from FVB/Nmice treated with environmental PAH mixtures

Creator:: Larkin, Andrew, Siddens, Lisbeth, and Krueger, Sharon
Abstract:: Epidermal RNA samples from FVB/N mice treated with PAH standards and environmental PAH mixtures were harvested and purified using Trizol extraction and RNeasy mini prep kit purification. Epidermal RNA integrity was low (RIN mean 3.5), indicating significant RNA degradation and the need to modify handling, collection, and processing of skin...
Resource Type:: Undergraduate Thesis and Presentation

Numerical solution of Hodgkin-Huxley's partial differential system for nerve conduction

Creator:: Morton, John Baird
Abstract:: A numerical solution to Hodgkin and Huxley's partial differential system for the propagated action potential is presented. In addition a three dimensional demonstration of the absolute refractory period is given. Lastly, theoretical evidence supporting Rushton's hypothesis is presented.
Resource Type:: Masters Thesis
Full Text:: Differential System For Nerve Conduction AN ABSTRACT OF THE THESIS OF JOHN BAIRD MORTON for the M. S

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Creator:: You, Hyekyoung Hannah
Abstract:: Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...
Resource Type:: Honors College Thesis
Full Text:: Environmental and Molecular Toxicology/Linus Pauling Institute William M. Baird, Committee Member

Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

Creator:: Shenvi, Swapna V.
Abstract:: Glutathione (GSH) is the predominant low molecular weight thiol antioxidant in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...
Resource Type:: Dissertation
Full Text:: like to thank my graduate committee members, Drs. William Baird, Balz Frei, Jeffrey Greenwood, and

Thermal ecology of the garter snakes Thamnophis sirtalis concinnus (Hallowell) and Thamnophis ordinoides (Baird & Girard)

Creator:: Stewart, Glenn R.
Abstract:: In recent years, studies dealing with temperature regulation, temperature sensitivity, and physiological responses to temperature in lizards and other reptiles have increased tremendously. It is notable that snakes have been largely ignored in such studies. This no doubt is due to their less direct relationship to ancestral endotherms. However, problems...
Resource Type:: Dissertation
Full Text:: concinnus (Hallowell) and Thamnophis ordinoides (Baird & Girard) AN ABSTRACT OF THE THESIS OF GLENN R

An analysis of a population of snowshoe hares, Lepus americanus washingtonii Baird, in western Oregon

Creator:: Black, Hugh C., 1941-
Abstract:: The ecology of a population of snowshoe hares, Lepus americanus washingtonii, was studied in western Oregon from 1960 to 1962. Objectives were to obtain information to control hares, which frequently cause damage to coniferous reproduction in the region, and to compare the life history of this little-studied subspecies with others....
Resource Type:: Dissertation
Full Text:: americanus washingtonii baird, in western Oregon AN ABSTRACT OF THE THESIS OF HUGH CLARK BLACK for the Ph

ScholarsArchive@OSU

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

Adapting computer science technologies to bridge critical gaps in proposed Tox21 risk assessment programs

A comparison between Portland Community College and Seattle Community College for determination of organizational efficiency

Method development for extraction and purification of dermal RNA from FVB/Nmice treated with environmental PAH mixtures

Numerical solution of Hodgkin-Huxley's partial differential system for nerve conduction

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

Thermal ecology of the garter snakes Thamnophis sirtalis concinnus (Hallowell) and Thamnophis ordinoides (Baird & Girard)

An analysis of a population of snowshoe hares, Lepus americanus washingtonii Baird, in western Oregon

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